综合行为干预疗法配合硫必利治疗小儿抽动障碍的效果观察

Observation of effect of comprehensive behavioral intervention therapy combined with tiapride on tic disorders in children

目的探讨综合行为干预疗法(CBIT)配合硫必利对抽动障碍(TD)患儿的干预效果。方法抽取郑州大学附属儿童医院2019年7月至2022年2月收治的74例TD患儿作为研究对象,按照随机数字表法分为CBIT组和西医组,每组37例。西医组给予硫必利治疗,CBIT组是在西医组基础上给予CBIT治疗。比较两组临床疗效、抽动症状改善情况[耶鲁综合抽动严重程度量表(YGTSS)]、功能损害[巴氏指数(BI)、精细运动能力测试量表(FMFM)、儿童疼痛行为量表(FLACC)]和不良反应发生情况。结果CBIT组总有效率(94.59%,35/37)高于西医组(78.38%,29/37),P<0.05。治疗后,CBIT组干扰程度、复杂程度及抽动强度、频率、类型评分低于西医组(P<0.05),BI、FMFM评分高于西医组(P<0.05),FLACC评分低于西医组(P<0.05)。治疗过程中,CBIT组不良反应发生率(8.11%,3/37)与西医组(5.41%,2/37)比较,差异未见统计学意义(P>0.05)。结论CBIT配合硫必利治疗TD效果较好,能有效改善患儿抽动症状,缓解功能受损。

Objective To investigate the intervention effects of comprehensive behavioral intervention therapy(CBIT)combined with thiopride on tic disorders in children.Methods Seveny-four children with TD admitted to Children’s Hospital Affiliated to Zhengzhou University from July 2019 to February 2022 were selected as research subjects,and they were divided into CBIT group and western medicine group by random number table method,with 37 cases in each group.The western medicine group was given thiopride,and the CBIT group was given CBIT based on the treatment of the western medicine group.The clinical efficacy,improvement in tic symptoms assessed by Yale General Tic Severity Scale(YGTSS),functional impairment assessed by Bartholomew index(BI),Fine Motor Function Measure(FMFM)and Face,Legs,Activity,Cry and Consolability(FLACC),and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the CBIT group(94.59%,35/37)was higher than that of the western medicine group(78.38%,29/37),P<0.05.The degree of interference,complexity and twitch intensity,frequency and type scores in the CBIT group were lower than those in the western medicine group after treatment(P<0.05).The BI and FMFM scores of the CBIT group were higher,and the FLACC score of the CBIT group was lower after treatment,compared with the western medicine group(P<0.05).During the treatment,there was no difference in the incidence of adverse reactions between the CBIT group(8.11%,3/37)and the western medicine group(5.41%,2/37),P>0.05.Conclusions CBIT combined with thiopride is effective in treatment of TD,and it can effectively improve tic disorders and alleviate functional impairment in children.