体质指数及脂肪百分比与女性发生骨质疏松症的相关性

Correlation of body mass index and percentage of body fat with osteoporosis in females

目的探讨体质指数(BMI)、脂肪百分比(PBF)与女性发生骨质疏松症(OP)的关系。方法抽取2019年2月至2022年2月于河南省人民医院进行健康体检的205例绝经后女性为研究对象。所有研究对象于就诊时均接受定量CT(QCT)检查,采用QCT Pro(V6.1)测量研究对象第1~3腰椎三节椎体平均骨密度值(BMD),依据相关指南评估其OP发生情况并将研究对象分为发生组与未发生组;采用人体成分分析仪获得研究对象的BMI、PBF值,同时收集研究对象受教育程度、绝经时间、婚姻状况等基本信息。采用组间差异性分析、Pearson相关性分析、多因素Logistic回归分析进行相关性分析,并绘制受试者工作特征曲线。结果经评估,205例女性发生OP 78例,占38.05%。发生组腰椎BMD、BMI、PBF均低于未发生组,差异有统计学意义(P<0.05);两组其他基线资料比较差异未见统计学意义(P>0.05)。双变量Pearson直线相关性检验结果显示,BMI与女性腰椎BMD值呈正相关(r>0,P<0.05);PBF与腰椎BMD值未见相关性(P>0.05)。Logistic回归分析结果显示,BMI、PBF低表达与女性发生OP有关(P<0.05)。受试者工作特征曲线结果显示,BMI、PBF单独及联合预测女性发生OP的曲线下面积分别为0.612、0.655、0.702,具有一定的预测价值。结论BMI、PBF与女性OP的发生具有一定的关系,二者低表达可导致女性OP发生率增高,但BMI、PBF预测女性发生OP的效能较低。

Objective To investigate the correlation of body mass index(BMI)and percentage of body fat(PBF)with osteoporosis(OP)in females.Methods Two hundred and five women during menopause who underwent physical examination in Henan Provincial People’s Hospital from February 2019 to February 2022 were selected as the research subjects.All of them underwent quantitative computed tomography(QCT)examination at the time of visit,the average bone mineral density(BMD)of the first to third lumbar vertebrae were measured by QCT Pro(V6.1),and then,the study object were divided into occurrence group and non-occurrence group according to the occurrence of OP,which evaluated by relevant guidelines.Body composition analyzer was used to obtain the BMI and PBF values of the subjects,and general information,such as education level,menopause time and marital status,of the subjects were collected at the same time.Inter-group difference analysis,Pearson correlation analysis and multi-variate Logistic regression analysis were used for correlation analysis,and the receiver operating characteristic curve of subjects was drawn.Results After evaluation,78 of 205 women had OP,accounting for 38.05%.The BMD,BMI and PBF of lumbar vertebra in the occurrence group were lower than those in the non-occurrence group,and the difference was significant(P<0.05);but there was no significant difference in other general data between the two groups(P>0.05).The results of the bi-variate Pearson linear correlation test showed that BMI was positively correlated with BMD of lumbar vertebra in females(r>0,P<0.05);PBF had no relationship with BMD of lumbar vertebra(P>0.05).The results of Logistic regression analysis showed that low expression levels of BMI and PBF were associated with occurrence of OP in females(P<0.05).The results of receiver operating characteristic curve showed that the area under the curve of BMI,PBF alone and combination of the two in predicting female OP were 0.612,0.655 and 0.702 respectively,which had certain predictive value.Conclusions BMI and PBF have certain correlation with the occurrence of female OP.Low expression of the two indicators can increase the incidence of female OP,but BMI and PBF are less effective in predicting female OP.