半夏泻心汤加减联合四联药物治疗幽门螺杆菌阳性胃溃疡的效果观察

Observation of effect of modified Banxia Xiexin decoction combined with quadruple therapy on positive helicobacter pylori-gastric ulcer

目的探究半夏泻心汤加减联合四联药物治疗幽门螺旋杆菌(Hp)阳性胃溃疡的临床疗效。方法抽取2019年2月至2021年2月河南中医药大学第三附属医院收治的60例Hp阳性胃溃疡患者,采用随机数字表法将其分为对照组(四联药物治疗)和研究组(半夏泻心汤加减联合四联药物治疗),每组30例。分析比较两组患者的治疗效果和Hp清除率,治疗前后的中医证候积分及胃泌素(GAS)、胃动素(MLT)水平。结果治疗前,两组中医证候积分比较差异未见统计学意义(P>0.05);治疗后,研究组中医证候积分低于对照组(P<0.05)。研究组总有效率(96.67%,29/30)与对照组(90.00%,27/30)比较差异未见统计学意义(P>0.05),但研究组Hp清除率(90.00%,28/30)高于对照组(70.00%,21/30),P<0.05。治疗前,两组GAS、MLT比较差异未见统计学意义(P>0.05);治疗后,研究组GAS、MLT指标均高于对照组(P均<0.05)。结论采取半夏泻心汤加减联合四联药物治疗Hp阳性胃溃疡,可显著改善患者的临床症状及预后,促进胃肠功能恢复,提升Hp清除率。

Objective To study the therapeutic effect of modified Banxia Xiexin decoction combined with quadruple therapy on positive helicobacter pylori(Hp)-gastric ulcer.Methods Sixty patients with Hp-positive gastric ulcer admitted to the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine from February 2019 to February 2021 were selected,and they were divided into control group(treated with quadruple therapy)and study group(treated with Banxia Xiexin decoction combined with quadruple therapy)by random number table method,with 30 cases in each group.The treatment effect and the Hp clearance rate of the two groups were compared,and the preoperative and postoperative traditional Chinese medicine(TCM)syndrome score and the levels of gastrin(GAS)and motilin(MLT)were analyzed and compared.Results Before treatment,there was no significant difference in TCM syndrome score between the two groups(P>0.05).After treatment,the TCM syndrome score of the study group was lower than that of the control group(P<0.05).There was no significant difference in the total effective rate between the study group(96.67%,29/30)and the control group(90.00%,27/30),P>0.05;however,the Hp clearance rate in the study group(90.00%,27/30)was higher than that in the control group(70.00%,21/30),P<0.05.Before treatment,there was no significant difference in levels of GAS and MLT between the two groups(P>0.05);after treatment,the levels of GAS and MLT in the study group were higher than those in the control group(all P<0.05).Conclusions The modified Banxia Xiexin decoction combiend with quadruple therapy can effectively alleviate the clinical symptoms and the prognosis,improve gastrointestinal function recovery,increase the Hp clearance rates in patients with Hp-positive gastric ulcer.