肺泡表面活性物质联合无创通气治疗新生儿呼吸窘迫综合征的作用评估

Evaluation of the Effect of Pulmonary Surfactant Combined with Noninvasive Ventilation in the Treatment of Neonatal Respiratory Distress Syn⁃drome

目的对新生儿呼吸窘迫综合征给肺泡表面活性物质联合无创通气治疗效果进行探讨。方法随机选取2016年1月—2021年12月盐城市第三人民医院收治的90例新生儿呼吸窘迫综合征患儿为研究对象,采用数字随机表法分为两组,每组45例。对照组采用单纯无创通气治疗,观察组在无创通气治疗时补充肺袍表面活性物质治疗,比较两组治疗后具体恢复情况。结果观察组气管插管率为2.22%、支气管肺发育不良率为2.22%、总并发症发生率为6.67%,均低于对照组的17.78%、17.78%、24.44%,差异有统计学意义(χ^(2)=4.444、4.444、5.414,P=0.035、0.035、0.020)。观察组无创通气时间、撤机后氧支持时间、住院时间及呼吸稳定时间短于对照组,上机24 h后肺氧合功能优于对照组,差异有统计学意义(P<0.05)。结论肺泡表面活性物质联合无创通气治疗新生儿呼吸窘迫综合征的临床效果显著。

Objective To explore the effect of pulmonary surfactant combined with non-invasive ventilation in neona⁃tal respiratory distress syndrome.Methods A total of 90 children with neonatal respiratory distress syndrome admitted to the Third People's Hospital of Yancheng City from January 2016 to December 2021 were randomly selected as the research objects and divided into two groups with 45 cases in each group by numerical random table method.The con⁃trol group was treated with non-invasive ventilation alone,and the observation group was treated with pulmonary sur⁃factant supplemented with non-invasive ventilation.The specific recovery of the two groups after treatment was com⁃pared.Results Observation group endotracheal intubation rate was 2.22%,the bronchial lung development defective rate was 2.22%,total complication rate was 6.67%,which were lower than those of the control group 17.78%,17.78%,24.44%,the difference was statistically significant(χ^(2)=4.444,4.444,5.414,P=0.035,0.035,0.020).The non-invasive ventilation time,oxygen support time,hospital stay and respiratory stabilization time of the observation group were shorter than those of the control group,and the pulmonary oxygenation function of the observation group was better than that of the control group after 24 h on the machine,the difference was statistically significant(P<0.05).Conclu⁃sion Plumonary surfactant combined with noninvasive ventilation is effective in the treatment of neonatal respiratory distress syndrome.