评价左卡尼汀配合蔗糖铁注射液治疗维持性血液透析期间并发肾性贫血的效果

Evaluation of the Effect of Levocarnitine Combined with Iron Sucrose Injection in the Treatment of Renal Anemia during Maintenance Hemodialysis

目的研究维持性血液透析并发肾性贫血开展左卡尼汀配合蔗糖铁注射液治疗的临床效果。方法方便选取2020年4月—2021年6月间聊城市第二人民医院收治入院的68例维持性血液透析的肾性贫血患者为研究对象,以随机数字表法分为常规组(n=34)和研讨组(n=34)。常规组开展蔗糖铁注射液治疗,研讨组开展蔗糖铁注射液+左卡尼汀治疗,对比两组临床疗效、贫血指标(血红蛋白、血细胞比容、红细胞、前白蛋白)、不良反应(血管刺激、皮疹、胃肠道反应)及氧化应激指标。结果研讨组总治疗有效率为94.12%,高于常规组,差异有统计学意义(χ^(2)=4.220,P=0.039)。研讨组患者治疗后血红蛋白(118.48±14.27)g/L、血细胞比容(36.24±3.49)%、前白蛋白(0.32±0.07)g/L及红细胞(2.43±0.46)×10^(12)/L指标均较常规组更高,差异有统计学意义(t=4.637、5.150、5.692、4.078,P<0.05)。两组不良反应发生情况比较,差异无统计学意义(P>0.05)。研究组氧化应激指标改善效果优于常规组,差异有统计学意义(P<0.05)。结论左卡尼汀配合蔗糖铁注射液治疗维持性血液透析并发肾性贫血可提高总体治疗效果,在改善患者贫血症状方面的效果显著,且不会增加药物不良反应。

Objective To study the clinical efficacy of levocarnitine combined with sucrose iron injection in the treatment of renal anemia complicated by maintenance hemodialysis.Methods 68 patients with renal anemia admitted to Liaocheng Second People's Hospital from April 2020 to June 2021 were conveniently selected as the study subjects.They were randomly divided into a conventional group(n=34)and a study group(n=34)using a random number table method.The conventional group received treatment with sucrose iron injection,while the study group received treatment with sucrose iron injection and levocarnitine.The clinical efficacy,anemia indicators(hemoglobin,hematocrit,red blood cells,prealbumin),adverse reactions(vascular stimulation,rash,gastrointestinal reaction),and oxidative stress indicators were compared between the two groups.Results The total effective rate of treatment in the study group was 94.12%,higher than that in the conventional group,and the difference was statistically significan(χ^(2)=4.220,P=0.039).After treatment,the patients in the study group had hemoglobin(118.48±14.27)g/L,hematocrit(36.24±3.49)%,prealbumin(0.32±0.07)g/L,and red blood cells(2.43±0.46)×10^(12)/L indicators were higher than those of the conventional group,and the difference was statistically significan(t=4.637,5.150,5.692,4.078,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).The improvement effect of oxidative stress indicators in the rstudy group was better than that in the conventional group,and the difference was statistically significan(P<0.05).Conclusion The combination of levocarnitine and sucrose iron injection in the treatment of maintenance hemodialysis complicated with renal anemia can improve the overall treatment effect,significantly improve the anemia symptoms of patients,and do not increase drug adverse reactions.