早期强化导泻治疗急性有机磷农药中毒的疗效研究

Study on the Curative Effect of Early Intensive Catharsis in Treating Acute Organophosphorus Pesticide Poisoning

目的分析急性有机磷农药中毒使用早期强化导泻治疗的临床效果。方法回顾性抽取2016年1月—2019年10月厦门大学附属第一医院收治的急性有机农药中毒患者68例的临床资料,根据导泻方式的不同分为对照组与研究组,各34例,对照组接受常规导泻治疗,研究组接受早期强化导泻治疗,就两组患者首次排便时间、住院时间、住院费用、胆碱酯酶及C反应蛋白(CRP)指标进行组间比较。结果研究组患者首次排便时间(4.68±3.22)h、住院时间(6.28±1.58)d均短于对照组(13.58±2.72)h、(7.62±1.24)d,且住院费用(7948.34±83.98)元低于对照组(9124.64±91.64)元,差异有统计学意义(t=12.312、3.890、55.181,P<0.05)。研究组患者入院后48 h后胆碱酯酶(5.23±0.72)U/L高于对照组的(4.39±0.82)U/L,CRP(6.32±1.62)ng/mL低于对照组的(7.13±1.24)ng/mL,差异有统计学意义(t=4.488、2.315,P<0.05)。结论对于急性有机磷农药中毒患者给予早期强化导泻治疗,能提升治疗效果,强化导泻作用,促使毒性物质迅速排出。

Objective To analyze the clinical effect of early intensive catharsis for acute organophosphorus pesticide poisoning.Methods A total of 68 patients clinical data with acute organic pesticide poisoning admitted to the First Affiliated Hospital of Xiamen University from January 2016 to October 2019 were retrospectively selected as the study subjects.They were divided into a control group and a study group,with 34 patients in each group.The control group received routine catharsis treatment,while the study group received early intensive catharsis treatment.The first defecation time,hospitalization time,and hospitalization cost of the two groups of patients were compared Cholinesterase and C-reactive protein(CRP)were compared among groups.Results The first defecation time(4.68±3.22)h and hospital stay(6.28±1.58)d in the study group were shorter than those in the control group(13.58±2.72)h and(7.62±1.24)d.And the hospitalization cost(7948.34±83.98)yuan was lower than that of the control group(9124.64±91.64)yuan,and the difference was statistically significant(t=12.312,3.890,55.181,P<0.05).48 h after admission,cholinesterase(5.23±0.72)U/L in the study group was higher than that in the control group(4.39±0.82)U/L,CRP(6.32±1.62)ng/ml was lower than that in the control group(7.13±1.24)ng/mL,the difference was statistically significant(t=4.488,2.315,P<0.05).Conclusion For patients with acute organophosphorus pesticide poisoning,early intensive catharsis treatment can improve the therapeutic effect,strengthen the catharsis effect,and promote the rapid discharge of toxic substances.