瘢痕疙瘩手术切除联合局部放疗及肉毒毒素局部注射的疗效

Curative Effect of Keloid Surgical Resection Combined with Local Radiotherapy and Local Injection of Botulinum Toxin

目的探讨瘢痕疙瘩手术切除联合局部放疗及肉毒毒素局部注射的疗效。方法简单随机选取2020年3月—2021年4月广东省肇庆市第一人民医院接收的瘢痕疙瘩患者70例,随机分为两组,各35例。对照组接受常规手术切除治疗,观察组行手术切除联合局部放疗及肉毒毒素局部注射治疗。观察比较两组治疗效果,术前及术后1、3、6个月瘢痕疙瘩积分以及不良反应发生情况。结果观察组患者治疗总有效率为97.14%,高于对照组的77.14%,差异有统计学意义(χ^(2)=4.590,P=0.032)。术前,两组患者瘢痕疙瘩积分比较,差异无统计学意义(P>0.05);观察组术后1、3、6个月瘢痕疙瘩积分为(5.21±6.77)分、(2.88±4.02)分、(1.36±7.54)分,均优于对照组,差异有统计学意义(t=10.297、9.467、12.971,P<0.05)。观察组治疗后不良事件发生率为14.29%,低于对照组的45.71%,差异有统计学意义(χ^(2)=8.231,P<0.05)。结论手术切除联合局部放疗及肉毒毒素局部注射对瘢痕疙瘩的治疗效果显著,安全性好,并且有助于提高治疗效果。

Objective To discuss the curative effect of keloid surgical resection combined with local radiotherapy and local injection of botulinum toxin.Methods 70 patients with keloid admitted to the First People's Hospital of Zhaoqing City,Guangdong Province from March 2020 to April 2021 were simple randomly selected and divided into two groups,with 35 patients in each group.The control group received routine surgical resection treatment,while the observation group received surgical resection combined with local radiotherapy and local injection of botulinum toxin.Observed and compared the treatment effects,keloid scores,and incidence of adverse reactions between the two groups before and 1,3,and 6 months after surgery.Results The total effective rate of the observation group patients was 97.14%,which was higher than the control group 77.14%,and the difference was statistically significan(χ^(2)=4.590,P=0.032).Before surgery,the difference was no statistically significant in the score of keloids between the two groups of patients(P>0.05);the keloid scores of the observation group at 1 month,3 months,and 6 months after surgery were(5.21±6.77)points,(2.88±4.02)points,and(1.36±7.54)points,all of which were better than those of the control group,and the difference was statistically significan(t=10.297,9.467,12.971,P<0.05).The incidence rate of adverse events after treatment in the observation group was 14.29%,lower than 45.71%in the control group,and the difference was statistically significan(χ^(2)=8.231,P<0.05).Conclusion Surgical resection combined with local radiotherapy and local injection of botulinum toxin has a significant therapeutic effect on keloids,good safety,and helps to improve the treatment effect.