IL-2及MDA在一氧化碳中毒迟发性脑病患者中血清的表达及临床意义

Expression and clinical significance of serum IL-2 and MDA in patients with delayed

目的:研究白细胞介素-2(IL-2)及丙二醛(MDA)在一氧化碳中毒迟发性脑病(DEACMP)患者血清的表达,探讨IL-2、MDA浓度检测对DEACMP早期诊断的指导意义。方法:选取接受治疗的40例一氧化碳中毒迟发性脑病患者作为研究组。选取同时期在医院体检科进行常规体检的健康人群40例为对照组。根据蒙特利尔认知评分(MOCA),将DEACMP患者分为轻度、中度及重度认知障碍组三组。同时根据Barthel指数,将DEACMP患者分为轻度、中度及重度功能障碍组。比较DEACMP患者与正常对照人群IL-2和MDA浓度水平的差异,研究不同认知障碍组及神经功能障碍组患者血清IL-2和MDA的表达差异。结果:与对照组比较,DEACMP患者血清IL-2水平更低,差异有统计学意义(P<0.05)。DEACMP患者治疗后血清IL-2浓度水平较刚入院时回升,两者差异有统计学意义(P<0.05)。MDA在DEACMP患者血清表达明显高于健康对照人群MDA的表达(P<0.05)。治疗后血清MDA浓度较刚入院时明显下降(P<0.05)。IL-2在重度认知障碍组患者血清的表达明显低于中度及轻度认知障碍组(P<0.05);MDA在重度认知障碍组患者的表达则明显高于中度及轻度认知障碍迟发性脑病患者(P<0.05)。IL-2及MDA浓度变化与MOCA评分无明显相关性(P>0.05)。IL-2在重度功能障碍组患者的表达明显低于中度及轻度功能障碍组(P<0.05),MDA在重度功能障碍组的表达高于中度与轻度功能障碍组(P<0.05)。IL-2和MDA表达变化与Barthel指数无明显相关性(P>0.05)。结论:IL-2和MDA表达水平有助于对DEACMP的诊断预判及病情评估。

Objective To study the expression of serum interleukin-2(IL-2)and malondialdehyde(MDA)in patients with delayed encephalopathy after carbon monoxide poisoning(DEACMP),and the guiding significance of the detection of IL-2 and MDA levels in the early diagnosis and judgment of delayed encephalopathy caused by carbon monoxide poisoning.Method 40 cases of delayed encephalopathy due to carbon monoxide poisoning admitted to the hospital were selected as the research group.40 healthy people who had physical examination in the physical examination center of the hospital were selected as the control group.According to the MOCA score,DEACMP patients were divided into mild cognitive impairment group,moderate cognitive impairment group and severe cognitive impairment group.According to Barthel index,the DEACMP group was divided into mild dysfunction group,moderate dysfunction group and severe dysfunction group.Objective to study the expression of serum IL-2 and MDA in patients with delayed encephalopathy caused by carbon monoxide poisoning,to study the differences of serum IL-2 and MDA expression in different cognitive impairment groups of patients and different neurological dysfunction groups.Results The serum IL-2 concentration in DEACMP group was significantly lower than that in normal control group(P<0.05).The concentration of IL-2 in DEACMP group was significantly higher than that in DEACMP group after 14 days of treatment(P<0.05).The serum MDA concentration in DEACMP group was significantly higher than that in normal control group(P<0.05).After treatment,the concentration of MDA in DEACMP group was significantly lower than that at admission(P<0.05).According to MOCA score,the serum IL-2 concentration of severe cognitive impairment group was significantly lower than that of moderate cognitive impairment group and mild cognitive impairment group(P<0.05),and the serum MDA concentration of severe cognitive impairment group was significantly higher than that of moderate cognitive impairment group and mild cognitive impairment group(P<0.05).There was no significant correlation between the expression of IL-2 and MDA and MOCA score(P>0.05).According to Barthel index,serum IL-2 concentration in severe dysfunction group was significantly lower than that in moderate dysfunction group and mild dysfunction group(P<0.05),and serum MDA concentration in severe dysfunction group was significantly higher than that in moderate dysfunction group and mild dysfunction group(P<0.05).There was no significant correlation between the expression of IL-2 and MDA and Barthel Index(P>0.05).Conclusion The detection of IL-2 and MDA levels has certain reference value for early diagnosis and evaluation of delayed encephalopathy caused by carbon monoxide poisoning.