甘露糖调控GLUT1/SLIT2通路抑制三阴性乳腺癌增殖的影响及机制研究

Effect of mannose regulating GLUT1/SLIT2 pathway on progressionof triple-negative breast cancer

乳腺癌是最常见的女性恶性肿瘤之一。目前认为,肿瘤细胞主要通过糖酵解途径摄取葡萄糖。甘露糖对肿瘤的影响备受关注,其抗肿瘤机制与癌细胞糖代谢密切相关。文章通过体外体内实验,观察甘露糖对乳腺癌增殖以及GLUT1,SLIT2,ROBO1蛋白表达的影响,旨在寻求调控乳腺癌增殖的新靶点,为临床诊断治疗乳腺癌提供理论依据。研究结果表明,甘露糖可抑制三阴性乳腺癌细胞的增殖及迁移能力,其机制可能与甘露糖调控GLUT1/SLIT2/ROBO1信号轴相关。

Breast cancer is one of the most common female malignant tumors.At present,it is believed that tumor cells mainly take glucose through glycolysis.Recent years,more and more research has been focused on the effect of mannose on tumor.The antitumor mechanism of mannose is closely related to glycolysis.This study is to explore the effect of mannose on the proliferation of triple negative breast cancer cells and its molecular mechanism.The effect of mannose on the proliferation and the expression of GLUT1,SLIT2,ROBO1 proteins of breast cancer cells was observed in vitro and in vivo.The purpose is to seek new targets to regulate the proliferation of triple-negative breast cancer cells and provide the basis of theory for the treatment of breast cancer.Mannose inhibits the progression and migration of triple-negative breast cancer.The mechanism may be related to the regulation of GLUT1/SLIT2/ROBO1 pathway by mannose.