趋化因子受体3及相关趋化因子在心血管疾病中的研究进展

The research progress of chemokine receptor 3 and related chemokines in cardiovascular disease

趋化因子受体3(CXCR3),一种表达在T细胞上的G蛋白偶联受体,可由趋化因子激活,在免疫和炎症中起着重要的作用。研究表明,CXCR3及其配体参与了多种不同病因的心血管疾病,包括动脉粥样硬化、高血压、心肌梗死、心肌炎、心力衰竭。本文旨在总结趋化因子在心血管疾病中的研究进展。

Chemokine receptor 3(CXCR3),a G protein-coupled receptor expressed on T cells that can be activated by chemokines,plays an important role in immunity and inflammation.Studies have shown that CXCR3 and its ligands are involved in cardiovascular diseases of various etiologies,including atherosclerosis,hypertension,myocardial infarction,myocarditis,and heart failure.This review aims to summarize the research progress of chemokines in cardiovascular diseases.