中药冰片干预脑缺血再灌注损伤机制的研究进展

Research Progress on Mechanism of Bingpian(Borneol)in Intervention of Cerebral Ischemia-Reperfusion Injury

人口老龄化的日益严重带来了心脑血管事件几率的增加,心脑血管事件之后的脑部缺血再灌注损伤的早期干预和治疗仍是一个难题。脑缺血再灌注损伤在现代医学中是一个复杂的瀑布级联反应,现代医学治疗通常需要多种药物联合使用,多种药物的联合使用对患者本身稳态也许会产生影响。而在传统医学中没有明确的分类,但可以归为脑卒中的范畴。冰片在脑卒中的治疗中有着优异的临床效果,脑缺血再灌注也归属于脑卒中,因此冰片也可以进入脑缺血再灌注损伤的治疗中。从传统医学以及现代医学的角度探讨了冰片的药理作用,结合冰片抑制铁死亡和钙超载来保护脑神经和影响血脑屏障通透性等方面进行了综述,探讨了冰片干预脑缺血再灌注损伤的具体机制。

The increasingly serious aging of the population has brought about an increase in the incidence of cardiovascular and cerebrovascular events.The early intervention and treatment of cerebral ischemia reperfusion injury after cardiovascular and cerebrovascular events is still a difficult problem.Cerebral ischemia-reperfusion injury is a complex cascade reaction in modern medicine,and modern medical treatment usually requires the combined use of multiple drugs,which may affect the patients'homeostasis.In traditional Chinese medicine,there is no clear classification,but it can be classified into the category of stroke.Bingpian(Borneol)has excellent clinical effect in the treatment of cerebral apoplexy.Cerebral ischemia and reperfusion also belong to cerebral apoplexy,and so Bingpian(Borneol)can also be used in the treatment of cerebral ischemia and reperfusion injury.In this paper,the pharmacological effects of Bingpian(Borneol)were discussed from the perspectives of traditional Chinese and modern medicine,and the effects of Bingpian(Borneol)on cerebral ischemia-reperfusion injury were reviewed in terms of inhibiting iron death and calcium overload to protect cerebral nerves and affecting the permeability of blood-brain barrier.The specific mechanism of Bingpian(Borneol)on cerebral ischemia-reperfusion injury was discussed.