桑叶的降糖作用及机制研究进展

Research Progress on Hypoglycemic Action and Mechanism of Mulberry Leaf

糖尿病是一组以长期高血糖为主要特征的代谢综合征,由胰岛素分泌不足或作用缺陷导致,以血中葡萄糖水平升高为生化特征,以多饮、多食、多尿、消瘦、乏力为临床表现的代谢紊乱综合群。糖尿病在中医学中属于“消渴病”“、脾瘅”等疾病的范畴。桑叶是采自桑科植物桑的干燥叶,使用历史非常的悠久,功效也十分多样。现临床主要用于风热感冒、肺热咳嗽、肝阳上亢和目赤肿痛等证候。《本草纲目》等书籍记载了其治疗消渴病的功效,随着现代技术和医学的发展,发现了桑叶可以有效改善胰岛素抵抗、改变葡萄糖吸收,并且对胰岛细胞有抗凋亡等多种作用,本文就桑叶治疗糖尿病的机制及临床研究进展进行综述。

Diabetes mellitus is a group of long-term high blood sugar as the main features of the metabolic syndrome,caused by insufficient insulin secretion or function defect,with elevated levels of glucose in the blood biochemical characteristics,to drink more,polyphagia,polyuria,emaciation and weakness for the clinical manifestations of metabolic disorder integrated group.Diabetes in TCM belongs to the "XiaoKe","PiDan" category.Mulberry leaf is a dried leaf collected from the mulberry family.It has a long history of use and various effects.At present,it is mainly used for windheat cold,lung heat cough,hyperactivity of liver Yang and eye red swelling and pain."Compendium of materia medica" recorded in the books such as the efficacy of its treatment of collateral,along with the development of modern technology and medicine,found that the mulberry leaves can make changes to improve insulin resistance,glucose absorption,and has a variety of action such as antiapoptotic to the islet cells,in this paper,the mechanism and clinical data of mulberry leaves to treat diabetes progress were summarized.