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利胆化痰活血方对代谢综合征大鼠胆汁酸代谢的影响

Effect of Lidan Huatan Huoxue Recipe on Bile Acid Metabolism in MS Rats
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摘要 目的观察利胆化痰活血方(LHH)对代谢综合征SD大鼠胆汁酸代谢的影响。方法将24只雄性SD大鼠随机分为空白组(Control组,n=8)和模型组(Model组,n=16),Control组大鼠予普通饲料,Model组大鼠予高脂高糖高盐饲料喂养12周造模,成模后,将Model组按随机原则分代谢综合征组(MS组)与利胆化痰活血方组(LHH组),每组8只。LHH组灌胃6周后,对大鼠肝脏、粪便和血清取材进行胆汁酸检测。结果LHH干预6周,与MS组比较,LHH组大鼠粪便石胆酸(LCA)含量显著降低(P<0.05),肝组织牛磺石胆酸(TLCA)含量显著升高(P<0.05),血清样本中胆酸(CA)、鹅去氧胆酸(CDCA)含量显著升高(P<0.05)。结论LHH能够改善MS大鼠胆汁酸代谢。 Objective To observe the effect of Lidan Huatan Huoxue Recipe(LHH) on bile acid metabolism in rats with metabolic syndrome.Methods 24 male SD rats were randomly divided into blank group(Control group,n=8) and model group(Model group,n=16).The rats in control group were fed with ordinary diet,and the rats in model group were fed with high-fat,high sugar and high salt diet for 12 weeks.After modeling,the model group was randomly divided into metabolic syndrome group(MS group) and Lidan Huatan Huoxue Formula group(LHH group),8 rats in each group.After intragastric administration of Lidan Huatan Huoxue Formula in LHH group for 6 weeks,bile acids were detected in rat liver,cecum and feces.Results After 6 weeks of LHH intervention,compared with MS group,the content of fecal cholic acid(LCA) decreased significantly(P0.05),the content of taurocholic acid(TLCA) in liver tissue increased significantly(P0.05),and the contents of cholic acid(CA) and chenodeoxycholic acid(CDCA) in serum samples increased significantly(P0.05).Conclusion LHH can improve the metabolism of bile acid in MS rats.
作者 尚浩南 阮君 徐敏 张强 刘凯利 张力 肖铁刚 王兵 Shang Haonan;Ruan Jun;Xu Min;Zhang Qiang;Liu Kaili;Zhang Li;Xiao Tiegang;Wang Bing(Shanghai Sixth People's Hospital,Shanghai 200233,China;Shanghai municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)
出处 《世界科学技术-中医药现代化》 CSCD 北大核心 2023年第1期218-226,共9页 Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金 上海市卫生健康委员会上海市中医药传承和科技创新项目(ZYKC2019035):基于“少阳枢机不利”治疗代谢综合征防治缺血性脑血管病人工智能健康管理平台构建,负责人:王兵 上海市卫生健康委员会上海市进一步加快中医药传承创新发展三年行动计划(ZY(2021-2023)-0205-04):中西医结合旗舰医院建设(上海市第六人民医院),负责人:王兵 上海市综合医院中西医结合专项(ZHYY-ZXYJHZX-201910):小柴胡汤防治代谢综合征患者动脉粥样硬化的临床研究,负责人:王兵。
关键词 利胆化痰活血方 代谢综合征 胆汁酸代谢 石胆酸 Lidan Huatan Huoxue Decoction Metabolic syndrome Bile acid metabolism Lithocholic acid
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