沙库巴曲缬沙坦治疗原发性高血压的临床效果

Clinical effect of sacubitril valsartan in the treatment of essential hypertension

目的探讨沙库巴曲缬沙坦治疗原发性高血压的临床效果。方法选取我院2021年11月至2022年11月收治的80例原发性高血压患者作为研究对象,采用随机数字表法将其分为观察组(40例)和对照组(40例)。观察组给予沙库巴曲缬沙坦治疗,对照组给予缬沙坦治疗。比较两组的动态血压指标、血压变异性、血压负荷、杓型血压人数占比情况及心功能指标。结果治疗后,两组的24 h平均收缩压(24 h MSBP)、24 h平均舒张压(24 h MDBP)、白天平均收缩压(dMSBP)、白天平均舒张压(dMDBP)、夜间平均收缩压(nMSBP)、夜间平均舒张压(nMDBP)均降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的24 h收缩压变异性(24 h SBPV)、24 h舒张压变异性(24 h DBPV)、24 h收缩压负荷(24 h SBPL)、24 h舒张压负荷(24 h DBPL)均降低,且24 h SBPV、24 h DBPV低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的杓型血压占比高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组N末端前体脑钠肽(NT-proBNP)水平低于对照组,差异具有统计学意义(P<0.05)。结论沙库巴曲缬沙坦治疗原发性高血压的效果显著,可改善血压波动性、心功能,降低血压负荷,恢复血压昼夜节律,值得临床推广与应用。

Objective To investigate the clinical effect of sacubitril valsartan in the treatment of essential hypertension.Methods A total of 80 patients with essential hypertension admitted in our hospital from November 2021 to November 2022 were selected as the research objects and divided into observation group(40 cases)and control group(40 cases)by random number table method.The observation group was treated with sacubitril valsartan,and the control group was treated with valsartan.The ambulatory blood pressure indexes,blood pressure variability,blood pressure load,proportion of dipper blood pressure and cardiac function indexes were compared between the two groups.Results After treatment,the 24 h mean systolic blood pressure(24 h MSBP),24 h mean diastolic blood pressure(24 h MDBP),daytime mean systolic blood pressure(dMSBP),daytime mean diastolic blood pressure(dMDBP),nighttime mean systolic blood pressure(nMSBP)and nighttime mean diastolic blood pressure(nMDBP)in the two groups decreased,and those in the observation group were lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the 24 h systolic blood pressure variability(24 h SBPV),24 h diastolic blood pressure variability(24 h DBPV),24 h systolic blood pressure load(24 h SBPL)and 24 h diastolic blood pressure load(24 h DBPL)in the observation group decreased,and the 24 h SBPV,24 h DBPV were lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the proportion of dipper blood pressure in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the N-terminal pro-brain natriuretic peptide(NT-proBNP)level in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Sacubitril valsartan is effective in the treatment of essential hypertension,which can improve blood pressure fluctuation and cardiac function,reduce blood pressure load and restore blood pressure circadian rhythm,which is worthy of clinical promotion and application.