ncRNAs介导的MPP7上调与ccRCC的相关性研究

The correlation study between ncRNAs mediated upregulation of MPP7 and ccRCC

目的探讨棕榈酰化蛋白7(MPP7)在肾透明细胞癌(ccRCC)中的作用及其机制。方法基于肿瘤基因组图谱(TCGA)数据库的信息,利用R包对MPP7进行数据分析和可视化处理,分析MPP7表达与ccRCC预后及诊断、临床分期、独立预后因素等的相关性,预测与分析MPP7上游相关通路。结果MPP7上调是ccRCC预后良好的独立预后因素,HAGLR/FGD5-AS1-hsa-miR-19b-3p轴可能是ccRCC中最有潜力的MPP7上游ncRNA相关通路。结论ncRNAs介导的MPP7上调与ccRCC良好预后有关。

Objective To investigate the role of MPP7 in renal clear cell carcinoma(ccRCC)and its mechanism.Methods Based on the information of The Tumor Genome Atlas(TCGA)database,data analysis and visualization of MPP7 using R package were performed to analyze the correlation between MPP7 expression and ccRCC prognosis and diagnosis,clinical staging,and independent prognostic factors,and to predict and analyze MPP7 upstream related pathways.Results MPP7 upregulation was an independent prognostic factor for good prognosis of ccRCC,and HAGLR/FGD5-AS1-hsa-miR-19b-3p axis might be the most promising MPP7 upstream ncRNA-related pathway in ccRCC.Conclusion ncRNAs-mediated MPP7 upregulation is associated with good prognosis in ccRCC.