UA hs-CRP与腔隙性脑梗死认知能力的相关性

目的探讨腔隙性脑梗死(LI)患者尿酸(UA)、超敏C反应蛋白(hs-CRP)与认知能力的关系。方法收集2018年12月至2020年12月于本院神经内科诊治的LI患者202例的病例资料,依据简易智力状态检查量表(MMSE)评估将患者分为认知功能正常组64例、轻度认知障碍组72例、中度认知障碍组45例和重度认知障碍组21例,比较组间UA、hs-CRP水平,分析其与认知能力的相关性。结果UA、hs-CRP水平在重度认知障碍组最高,中度认知障碍组次之,认知功能正常组最低,组间差异有统计学意义(P<0.05);pearson相关系数分析示UA、hs-CRP与MMSE评分呈负相关(P<0.001)。结论UA、hs-CRP的水平与LI患者认知能力相关,其水平升高是LI患者出现认知障碍的危险因素,早期监测UA、hs-CRP水平并采取适当的治疗,可能对预防认知障碍的发生、改善预后有益。

Objective To investigate the relationship between uric acid(UA),Hypersensitive C-reactive protein(hs-CRP)and cognitive impairment in patients with lacunar cerebral infarction(LI).Methods 202 LI patients admitted to the first hospital of jiaxing neurology from December 2018 to December 2020 were collected.Based on the Mini-Mental State Exam(MMSE)they were divided into 64 cases of normal cognitive function group,72 cases of the mild cognitive impairment group,45 cases of the moderate cognitive impairment group and 21 cases of the severe cognitive impairment group.The levels of UA and Hs-CRP in 4 groups were compared,the correlation among UA,hs-CRP and cognitive ability in LI patients was analyzed.Results The levels of UA,hs-CRP in LI patients were the highest in the severe cognitive impairment group,followed by the moderate cognitive impairment group,and the lowest was in the normal cognitive function group,with statistical significance(P<0.05).The Pearson correlation analysis showed that MMSE scores of LI patients were negatively correlated with UA,hs-CRP,with statistical significance(P<0.001).Conclusion The levels of UA,hs-CRP are correlated to the cognitive impairment in LI patients,and the abnormal increase levels are risk factors for the occurrence of cognitive impairment in LI patients.Early monitoring of UA,hs-CRP levels and appropriate treatment can prevent the occurrence of cognitive impairment and improve the prognosis.