人参淫羊藿麦冬玛咖颗粒缓解小鼠运动性疲劳的实验研究

The Alleviative Effect of Ginseng Epimedii Folium Ophiopogonis Radix Maca Particles on Physical Fatigue in Mice

目的:采用小鼠游泳运动疲劳模型,研究人参淫羊藿麦冬玛咖颗粒缓解小鼠运动性疲劳的功效。方法:将SPF级别的雄性ICR小鼠按随机原则分为4组,分别为空白对照组,人参淫羊藿麦冬玛咖颗粒低、中、高剂量组,分别为3.67 g·kg^(-1)bw、7.33 g·kg^(-1)bw、11.00 g·kg^(-1)bw的灌胃量,每组10只小鼠。人参淫羊藿麦冬玛咖颗粒高、中、低3个剂量组灌胃30 d,空白对照组采用相同方式给予同等体积蒸馏水,检测小鼠负重游泳时间、血液乳酸、血液尿素氮与肝糖原,评价人参淫羊藿麦冬玛咖颗粒缓解体力疲劳的功效。结果:与空白对照组相比,人参淫羊藿麦冬玛咖颗粒的低、中、高剂量组游泳后血清尿素值及乳酸的曲线下面积均显著或极显著降低(P <0.05或P <0.01),中剂量组小鼠负重游泳维持时间明显增加(P <0.05)。结论:人参淫羊藿麦冬玛咖颗粒具有一定增强运动耐力和缓解体力疲劳的作用。

Objective:Study the effect of ginseng epimedii folium ophiopogonis radix maca particles in alleviating exercise-induced physical fatigue using an experimental model of weight-loading swimming in mice.Method:SPF male ICR mice were divided into normal control group,low,medium and high dose of ginseng epimedii folium ophiopogonis radix maca particles groups.The doses of gastric lavage of three dose groups were 3.67 g·kg^(-1) bw,7.33 g·kg^(-1) bw,11.00 g·kg^(-1) bw respectively with 10 mice in every group.Feed with test sample was given to mice by gavage feeding once a day for 30 days,and the control mice were given with the equal volume of distilled water.The effect of ginseng epimedii folium ophiopogonis radix maca particles on exercise-induced physical fatigue was evaluated by measuring the weight-bearing swimming time,blood lactic acid,blood urea nitrogen and liver glycogen of mice.Result:The levels of serum urea nitrogen and blood lactate acid in the three dose of ginseng epimedii folium ophiopogonis radix maca particles were significantly decreased(P<0.05 or P<0.01),and the swimming time with weight of the medium dose group was significantly increased(P<0.05)contrast with the control.Conclusion:Ginseng epimedii folium ophiopogonis radix maca particles have a strong positive effect on enhancing exercise endurance and alleviating physical fatigue.