摘要
根据骨形态发生蛋白(BMPs)现有研究探讨其在脂肪胰岛素抵抗中的作用机制.综述了在白色脂肪组织(WAT)和棕色脂肪组织(BAT)中的相关BMP信号通路,BMPs通过激活过氧化物酶体增生物激活受体γ(PPARγ)决定脂肪细胞命运和调节脂肪细胞功能来改善胰岛素敏感性.WAT中,BMPs促进脂肪分化、降低炎症、增强胰岛素信号以及葡萄糖转运;BAT中,可以增加棕色脂肪细胞以及增强其活性来促进产热.总结探讨了近年来BMPs在脂肪胰岛素抵抗中的作用进展,以期为脂肪胰岛素抵抗的防治提供新思路.
According to the existing researches on bone morphogenetic proteins(BMPs),their mechanism in adipose tissue insulin resistance was discussed.Relevant BMP signaling pathways in white adipose tissue(WAT)and brown adipose tissue(BAT) were reviewed,and BMPs improved the insulin sensitivity by the regulation of adipocyte fate and function through peroxisome proliferators activated receptor γ(PPARγ) activation.In WAT,BMPs can promote adipocyte differentiation,reduce infammation,enhance insulin signaling and glucose transport;In BAT,brown adipocytes can be increased and their activity can be enhanced to promote thermogenesis.This review summarized and discussed the role of BMPs in adipose tissue insulin resistance in recent years to provide new ideas for the prevention and treatment of insulin resistance.
作者
迪丽娜孜·阿布都吉力勒
樊栩
董昱良
马宇
王为兰
李金耀
DILINAZI Abudujilile;FAN Xu;DONG Yuliang;MA Yu;WANG Weilan;LI Jinyao(Xinjiang Key Laboratory of Biological Resources and Genetic Engineering,School of Life Science and Technology,Xinjiang University,Urumqi Xinjiang 830017,China)
出处
《新疆大学学报（自然科学版）（中英文）》
CAS
2023年第3期342-350,共9页
Journal of Xinjiang University(Natural Science Edition in Chinese and English)
基金
新疆维吾尔自治区自然科学青年基金“肉苁蓉苯乙醇苷改善脂肪细胞胰岛素抵抗的作用及机理研究”(2020D01C070)
新疆维吾尔自治区重点实验室开放课题“管花肉苁蓉苯乙醇苷调控代谢性炎症改善脂肪胰岛素抵抗的作用及其机制”(2021D04019)。
