辣木叶及其有效成分抗高脂血症药理作用研究进展

Research progress of anti-hyperlipidemia effects of Moringa oleifera leaves and its active components

辣木叶来源于热带植物辣木Moringa oleifera,以叶入药,具有良好的生理活性。现代研究显示辣木叶含有丰富的黄酮、多糖、多酚、生物碱等功能成分,具有明确的抗氧化、抗菌、降糖、抗高脂血症等药理作用。辣木叶及其有效成分可能通过抑制脂质过氧化、抑制胰脂肪酶活性、抑制α-葡萄糖苷酶活性、诱导棕色脂肪组织生成、提高胆汁酸结合能力等途径达到抗高脂血症作用。综述辣木叶及其有效成分抗高脂血症药理作用的研究进展,以期为利用该药用植物资源开发新药提供依据。

Moringa oleifera leaves are derived from Moringa oleifera Lam.and used as medicine.Modern studies have shown that M.oleifera leaves are rich in functional components such as flavonoids,polysaccharides,polyphenols and alkaloids,and have defined pharmacological effects such as antioxidant,antibacterial,hypoglycemic and anti-hyperlipidemia.M.oleifera leaves and its active components may achieve the anti-hyperlipidemia effect by inhibiting lipid peroxidation,inhibiting the activity of pancreatic lipase,inhibiting the activity ofα-glucosidase,inducing the formation of brown adipose tissue,and improving the bile acid binding ability.The research progress of the pharmacological effects of M.oleifera leaves and its active components on anti-hyperlipidemia are reviewed,in order to provide a basis for the development of new drugs for hyperlipidemia using the medicinal plant resources.