牙列缺失患者炎症因子的表达及其与口腔种植修复效果的关系

Expression of inflammatory factors in patients with dentition defect and its relationship with effect of oral implant repair

目的 探讨牙列缺失患者炎症因子的表达及其与口腔种植修复效果的关系,以期为后续诊治提供指导。方法 本研究采用偶遇抽样法,纳入信阳市人民医院2019年2月至2021年12月接受口腔种植修复治疗的117例牙列缺失患者,全部患者均于治疗结束后随访1个月,观察患者随访1个月时的口腔种植修复效果,并分为修复良好组和修复不良组。调查患者一般资料和实验室检查结果,并检测炎症因子:C-反应蛋白(CRP)、白介素-6(IL-6)、干扰素-γ(INF-γ)和肿瘤坏死因子-α(TNF-α),重点分析炎症因子和牙列缺失患者口腔种植修复效果的关系。结果 110例接受口腔种植修复的牙列缺失患者中,有18例口腔种植修复不良,占比为16.36%;修复不良组的CRP、INF-γ、IL-6和TNF-α水平均高于修复良好组(P<0.05);经点二列相关性检验,炎症因子CRP、INF-γ、IL-6和TNF-α均与牙列缺失患者口腔种植修复效果呈正相关性(r>0,P<0.05);经双变量Pearson相关系数检验,炎症因子CRP和TNF-α间、IL-6和TNF-α间呈正相关性(r>0,P<0.05)。结论 牙列缺失患者各炎症因子的表达与口腔种植修复效果密切相关,当各炎症因子水平升高时,提示患者口腔种植修复效果不良,可通过观察炎症因子水平来预估患者口腔种植修复效果,及时实施针对性治疗从而提高治疗效果。

【Objective】To investigate the expression of inflammatory factors in patients with dentition defect and its relationship with the effect of oral implant repair,so as to provide guidance for the follow-up diagnosis and treatment.【Methods】A total of 117 patients with dentition defect who received oral implant repair treatment in the hospital from February 2019 to December 2021 were enrolled in this study by chance sampling.All patients were followed up for 1 month after the treatment,and the effects of oral implant repair were observed when the patients were followed up for 1 month.They were divided into good repair group and poor repair group.The general data and laboratory examination results of patients were investigated,and the inflammatory factors including C-reactive protein(CRP),interleukin-6(IL-6),human interferonγ(INF-γ)and tumor necrosis factor-α(TNF-α)were detected.The relationship between inflammatory factors and the effect of oral implant repair in patients with dentition defect was analyzed.【Results】Among 110 patients with dentition defect who received oral implant repair,18 patients had poor oral implant repair,accounting for 16.36%.The levels of CRP,INF-γ,IL-6 and TNF-αin the poor repair group were higher than those in the good repair group,with a statistical significant difference(P<0.05).By point binary correlation test,the inflammatory factors CRP,INF-γ,IL-6 and TNF-αwere positively correlated with the effect of oral implant repair in patients with dentition defect(r>0,P<0.05).According to the bivariate Pearson correlation coefficient test,there was a positive correlation between CRP and TNF-α,and between IL-6 and TNF-α(r>0,P<0.05).【Conclusion】The expression of inflammatory factors in patients with dentition defect is closely related to the effect of oral implant repair.When the level of inflammatory factors increases,it indicates that the effect of oral implant repair is poor.The effect of oral implant repair can be estimated by observing the level of inflammatory factors,and targeted treatment can be implemented in time to improve the therapeutic effect.