中药活性物质对肠屏障功能的保护作用研究进展

Research progress in the protective effect of active substances of Chinese medicine on intestinal barrier function

肠屏障可以防止肠道内的有害物质从肠腔进入人体内其他组织、器官和血液循环中,以确保机体内部环境稳态。然而,肠屏障完整性可能受到诸如感染、肠道菌群改变、免疫失调等内在和外在因素的破坏,从而导致外部有害物质侵入机体内环境,引起消化系统疾病、免疫系统疾病或代谢性疾病。中药作为中国传统医学的瑰宝,具有特有的活性成分和明确的药理作用,对疾病有极其显著的治疗作用。本文就中药活性物质对肠屏障损伤的修复作用相关文献进行综述,为治疗肠屏障损伤提供新思路。

The intestinal barrier can prevent the passage of harmful substances from the intestinal lumen to other tissues and blood circulation to ensure the internal environmental homeostasis.However,the intestinal barrier integrity may be disrupted by intrinsic and extrinsic factors such as infection,altered intestinal flora,and immune dysregulation,which further disturbs the internal environmental homeostasis and cause digestive,immune and metabolic diseases.Chinese herbal medicine has significant therapeutic effects on human body with its unique active ingredients and pharmacological effects.This paper reviewed literatures on the protective effect of active substances of traditional Chinese medicine on intestinal barrier damage to provide new ideas for the treatment of intestinal barrier damage.