淫羊藿苷抗动脉粥样硬化的作用机制研究进展

Research progress on mechanism of icariin against atherosclerosis

动脉粥样硬化是一种慢性血管炎性疾病,内皮功能障碍是动脉粥样硬化病变的关键早期阶段。淫羊藿苷是从淫羊藿中分离出的类黄酮成分,具有多种药理作用,能减轻内皮细胞氧化损伤和细胞凋亡、抑制内皮–间充质转化进程、抑制平滑肌细胞增殖和迁移、阻止泡沫细胞形成、抑制炎症反应、调控多种miRNA的表达,从多种途径发挥抗动脉粥样硬化的作用。总结了淫羊藿苷抗动脉粥样硬化的作用机制,希望为淫羊藿苷的临床应用提供参考。

Atherosclerosis is a chronic vasculitis disease,and endothelial dysfunction is the key early stage of atherosclerosis.Icariin is a flavonoid component isolated from Epimedii Folium,which has various pharmacological effects.Icariin can alleviate the oxidative damage and apoptosis of endothelial cells,inhibit the process of endothelial mesenchymal transformation,inhibit the proliferation and migration of smooth muscle cells,prevent the formation of foam cells,reduce inflammatory reaction,regulate the expression of multiple miRNAs,and thus play the role of against atherosclerosis in various ways.This article summarized the mechanism of icariin against atherosclerosis,hoping to provide reference for the clinical application of icariin.