A型肉毒毒素治疗患儿臭汗症的效果

Effect of botulinum toxin type A on children with odorihidrosis

目的探讨A型肉毒毒素治疗患儿臭汗症的效果。方法2017年3月至2021年2月,联勤保障部队第980医院烧伤整形科收治臭汗症患儿121例,男48例、女73例,年龄13~17(15.9±1.2)岁。其中轻度组24例、中度组50例、重度组47例。根据腋毛区范围注射A型肉毒毒素,每侧注射20~50个点,每点注射A型肉毒毒素1 U,双侧注射总量50~100 U。随访6~9个月,观察疗效。结果3组患儿进行疗效评估,轻度组24例显效23例,占95.8%,全部有效;中度组50例显效46例,占92.0%,有效49例,占98.0%;重度组47例显效40例,占85.1%,有效45例,占95.7%。3组患儿有效率比较差异无统计学意义(P>0.05);轻、中度组的显效率均高于重度组,差异有统计学意义(P<0.05)。结论A型肉毒毒素治疗轻、中度患儿臭汗症疗效显著,值得临床应用。

Objective To investigate the effect of botulinum toxin type A on children with odorihidrosis.Methods From March 2017 to February 2021,121 children with odorihidrosis,including 48 males and 73 females,aged 13 to 17(15.9±1.2)years,were admitted to the Burn and Plastic Surgery Department of the 980 Hospital of PLA.There were 24 cases in mild group,50 cases in moderate group and 47 cases in severe group.Botulinum toxin A was injected into 20-50 points on each side,and 1 U was injected into each point.The total amount of botulinum toxin A was 50-100 U on both sides.Results Three groups of children were evaluated for efficacy,24 cases of mild group was significantly effective in 23 cases,accounting for 95.8%.In the moderate group,46(92.0%)of 50 cases showed obvious effect.49 cases(98.0%)were effective;In the severe group,40 cases(85.1%)showed obvious effect and 45 cases(95.7%)were effective.Three groups of children with different efficacy had no statistical significance(P>0.05).The significant efficiency in mild and moderate groups was higher than that in severe group,and the difference was statistically significant(P<0.05).Conclusions Botulinum toxin type A is effective in the treatment of children with mild and moderate bromhidrosis,and is worthy of clinical application.