基于现代文献挖掘中药外治寻常型银屑病用药规律

Research on the medication law of external application of TCM for psoriasis vulgaris based on modern articles

目的运用数据挖掘方法分析中药外用治疗寻常型银屑病(PV)用药规律。方法检索中国知识资源总库(CNKI)、中文科技期刊数据库(重庆维普)、中国学术期刊数据库(万方数据)、中国生物医学文献服务系统(SinoMed)、PubMed、Cochrane Library,时间为建库至2022年5月23日,获取中药外治PV的临床对照试验文献,筛选并提取中药方剂。借助中医传承计算平台V3.0软件,探析药物药性、药味、归经、功效,中药频次、常用药对及核心组合。结果纳入方剂186首,涉及中药190味,多为苦寒药,主要归肝、心经,以清热类为主,活血化瘀类、补虚类中药次之;使用频次较高的10味中药为苦参、白鲜皮、黄柏、地肤子、蛇床子、当归、丹参、土茯苓、生地黄、紫草;常用的3个药对是苦参-白鲜皮、苦参-蛇床子、苦参-地肤子;演化得到4个核心组合。结论中药外治PV围绕“热毒”核心病机,以“从血论治”为主,治以凉血解毒、活血化瘀、养血润燥,并重视清热燥湿、祛风止痒,可为临床治疗提供参考。

Objective To analyze the medication law of external application of TCM in the treatment of psoriasis vulgaris(PV)by using data mining method.Methods Clinical controlled trial literature about external application of TCM in the treatment of PV was retrieved from CNKI,VIP,WanFang,SinoMed,PubMed and Cochrane Library from the establishment of the databases to May 23,2022.Prescriptions were extracted after screening.TCM inheritance computing platform V3.0 was used to analyze the property,taste,meridian,efficacy,use frequency,common medicinal pairs and the core combinations.Results A total 186 prescriptions were included,involving 190 kinds of Chinese materia medica.The medicines were mostly bitter and cold in property and taste,mainly belonging to the liver and heart meridians.Heat-clearing drugs were mainly used,followed by blood circulation-activating and stasis-eliminating medicines,and tonic medicines.The ten most frequently used medicines were Sophorae Flavescentis Radix,Dictamni Cortex,Phellodendri Chinensis Cortex,Kochiae Fructus,Angelicae Sinensis Radix,Salviea Miltiorrhizae Radix et Rhizoma,Poria,Rehmannine Radix,and Arnebiae Radix;the 3 commonly used medicinal pairs were Sophorae Flavescentis Radix-Dictamni Cortex,Sophorae Flavescentis Radix-Cnidii Fructus,and Sophorae Flavescentis Radix-Kochiae Fructus;4 combinations were obtained through evolution.Conclusions External application of TCM for the treatment of PV is around the core pathogenesis of"heat toxin",mainly treating from the blood,including cooling blood and detoxifcation,activating blood circulation and removing stasis,nourishing the blood and moistening dryness.Clearing heat and drying dampness,dispelling wind and relieving itching are also valued.The treating thoughts can provide some references for clinical treatment.