RUNX家族在结直肠癌中的作用

Roles of RUNX family in colorectal cancer

结直肠癌的发病率逐年上升,尽管在放化疗和手术方面取得了进展,但其复发率仍然很高。与其他类型的癌症相比,结直肠癌患者的生存率虽然增加了,但仅持续了相对较短的时间(20个月)。Runt相关转录因子蛋白属于转录因子家族,在不同类型的癌症中都起着关键作用。本综述将分析Runt相关转录因子在结直肠癌发生、发展中的作用机制,表明其作为癌症生物标志物的重要性。此外,将强调继续进行Runt相关转录因子蛋白的双重功能研究的重要性,以期将其应用于结直肠癌的特定诊断和治疗。

The incidence of colorectal cancer has increased year by year,despite research progress in chemoradiotherapy and surgery,its recurrence rate remains high.Compared to other types of cancer,survival rates for colorectal cancer patients,although increased,lasted only for a relatively short period of time(20 months).RUNX proteins belong to a family of transcription factors and play a key role in different types of cancer.This review will analyze the mechanism of the RUNX family in the development and progression of colorectal cancer and show its importance as a cancer biomarker.In addition,the importance of continuing the dual function studies of RUNX proteins will be emphasized,in order to apply them in the specific diagnosis and treatment of colorectal cancer.