光动力疗法对口腔致病微生物影响的研究进展

Research Progress on Effects of Photodynamic Therapy on Oral Pathogenic Microorganisms

光动力疗法(photodynamic therapy,PDT)是一种非侵入性治疗,通过光敏剂在一定波长的可见光照射下发生化学效应达到治疗效果,具有不易产生耐药性、高度选择性、低毒微创性等优点,在抗癌和皮肤病临床治疗的应用前景备受关注。PDT作为一种新型抗菌疗法,对于口腔细菌、真菌和病毒引起的感染效果确切,且能克服口腔疾病治疗中机械手段无法彻底清除致病微生物、易引起耐药菌、安全性欠佳等难点,为口腔疾病治疗提供了新思路。本文就PDT的基本原理、构成及在口腔各类常见致病微生物杀伤效果的研究成果进行综述和展望。

Photodynamic therapy(PDT),a non-invasive treatment,will achieve therapeutic effect through biochemical effect of photosensitizer under visible light irradiation on a certain wavelength.It has the advantages of resistance prevention,high selectivity,low toxicity and minimal invasion,etc.,and its application prospect in the clinical treatment of cancer and skin diseases has attracted great attention.With the deepening of the research,PDT,as a new antibacterial therapy,has a definite effect on the infection caused by oral bacteria,fungi and viruses.Having overcome certain problems arising from mechanical treatment of oral diseases such as the failure to remove completely pathogenic microorganisms and likeness to induce drug-resistant bacteria,PDT provides a new way for treating oral diseases.In this paper,the basic principle,composition and killing effect of PDT on various common pathogenic microorganisms in oral cavity were reviewed and prospected.