核因子κB与特发性肺纤维化相关性的研究进展

Research progress in correlation between nuclear factor-κB and idiopathic pulmonary fibrosis

特发性肺纤维化(IPF)是一种年龄相关、进行性且通常致命的肺部疾病,缺乏有效的干预措施,其特征是持续的修复反应及肌成纤维细胞的积累和细胞外基质沉积的增加。核因子κB是一种转录因子,参与多种病理生理过程,近期大量研究证实,其在IPF发生、发展中起重要作用,是IPF的潜在治疗靶点。本文就核因子κB在IPF中的发生、发展、靶向治疗等相关研究进展进行综述。

Idiopathic pulmonary fibrosis(IPF)is an age-related,progressive,and often fatal lung disease that lacks effective interventions and is characterized by a continuous repair response and an increased myofibroblast accumulation and extracellular matrix deposition.Nuclear factor-κB is a transcription factor involved in a variety of pathophysiological processes.A large number of recent studies have confirmed that nuclear factor-κB plays an important role in the occurrence and development of IPF and is a potential therapeutic target of IPF.This review focuses on the research of the nuclear factor-κB in the occurrence and development of IPF and in the targeted therapy.