反式脂肪酸摄入量与乳腺癌发病风险的Meta分析

A Meta-Analysis of the Association between Trans Fatty Acid Intake and the Risk of Breast Cancer in Women

为探讨反式脂肪酸的摄入量及其在血清中的水平与女性乳腺癌发病风险的关系,检索Pubmed、ISI Web of Science、ProQuest、Science Direct、CNKI、万方、维普等中外数据库,依据系统综述和荟萃分析优先报告条目(PRISMA)进行文献选取、文献筛选、数据提取和质量评估。采用Stata 16.0软件对纳入研究进行Meta分析。结果表明:反式脂肪酸摄入量与女性患乳腺癌风险无关(合并效应量:0.99;95%CI:0.92~1.06;I^(2)=66.9%,P=0);共轭亚油酸摄入量与女性患乳腺癌风险呈正相关(合并效应量:1.09;95%CI:1.02~1.16;I^(2)=0,P=0.597);血清中反式脂肪酸的水平与乳腺癌发病风险无关(合并效应量:0.94;95%CI:0.47~1.42;I^(2)=85.3%,P=0)。

In order to investigate the relationship between the intake of trans fatty acids and their serum levels and the risk of female breast cancer,we searched Pubmed,ISI Web of Science,ProQuest,Science Direct,CNKI,Wanfang,Weipu and other domestic and foreign databases.Literature selection,literature screening,data acquisition and quality assessment were conducted based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA).Meta analysis of the included studies was performed using Stata 16.0 software.Results:Trans fatty acid intake was not associated with breast cancer risk in women(combined effect size:0.99;95%CI:0.92-1.06;I^(2)=66.9%,P=0);the intake of conjugated linoleic acid was positively related to the risk of breast cancer(combined effect size:1.09,95%CI:1.02-1.16,I^(2)=0,P=0.597).In addition,serum levels of trans fatty acids were not associated with breast cancer risk in women(combined effect size:0.94,95%CI:0.47-1.42;I^(2)=85.3%,P=0).