应用微通道反应器技术成对电合成葡萄糖酸锌和山梨醇

Paired Electro-Synthesis of Zinc Gluconate and Sorbitol by Microchannel Reactor

“电化学氧化葡萄糖制备葡萄糖酸锌”是一个本科生有机电合成实验,通常使用H型电解池作为反应器,存在着合成时间长、合成电压高、电流效率低等缺点。电化学微通道反应器可降低合成电压、有效增强传质。本实验以培养学生的独立思考和逻辑思维能力为导向,将这个实验改进为一个综合化学实验,通过自制的电化学微通道反应器进行成对电合成葡萄糖酸锌和山梨醇。教学过程中首先向学生介绍相关原理和基础知识,继而引导学生应用循环伏安法选择合适的合成电压,然后组装反应器进行成对电合成,最后进行产物的分离和鉴别并展开分析和讨论。通过本实验,学生将理解循环伏安法等电分析方法为什么能为电合成提供指导信息,理解成对电合成的优点,了解电化学微通道反应器新技术的应用优势,了解电化学合成与绿色化学的关系。本改进实验教学内容丰富,涉及电合成、电分析、滴定分析等多个典型实验技能,有助于学生在分析问题、解决问题的过程中培养科学思维和创新能力。

“Electrochemically oxidizing glucose to prepare zinc gluconate”is a typical organic synthesis experiment for undergraduates,in which H-cell is usually used as the reactor.There are some shortcomings,including the long synthesis time,the high applied voltage and the low current efficiency.A kind of new device,electrochemical microchannel reactor,can overcome these shortcomings,because of the decreased applied voltage and the enhanced mass transfer.Guided by the cultivation of students’independent thinking and logical thinking skills,this experiment improves the previous organic synthesis experiment into a comprehensive experiment,in which paired electrosynthesis of zinc gluconate and sorbitol is carried out through a home-made electrochemical microchannel reactor.In the teaching process,the principles and basic knowledge about electro-synthesis are introduced at first.Next,the students are guided to apply the cyclic voltammetry to select the appropriate applied voltage,then assemble the reactor to carry out the paired electro-synthesis.Finally,the products are separated and identified,and the results are analyzed and discussed.Through this experiment,students will understand why electroanalytical methods such as cyclic voltammetry can provide guiding information for electro-synthesis,the advantages of paired electro-synthesis,application advantages of new device of electrochemical microchannel reactors,and the relationship between organic electro-synthesis and green chemistry.The improved experiment has a rich teaching content,including electrosynthesis,electrochemical analysis,titration analysis and other typical laboratory skills,which helps students to cultivate scientific thinking and innovation ability in the process of analyzing and solving problems.