基于脑磁共振成像探讨冠状动脉钙化与认知障碍的潜在机制研究进展和展望

Research progress of coronary artery calcification and cognitive impairment and brain magnetic resonance imaging

冠状动脉钙化(coronary artery calcification, CAC)指冠脉粥样斑块内钙盐物质沉积引起的硬化,是冠状动脉粥样硬化的高度特异性标志物,CAC程度可定量分析,并以冠状动脉钙化积分(coronary artery calcification score, CACS)的方式呈现,且CACS与认知功能障碍(cognitive impairment, CI)关系密切。目前CAC与CI之间的发病机制和影响因素尚未阐明,本文从脑MRI角度出发对CAC伴CI的研究进展作一综述,分析目前在CAC与CI领域中已应用的脑MRI技术,提出不足与未来展望,以进一步探究CAC伴CI的神经病理机制。

Coronary artery calcification(CAC)refers to the sclerosis caused by calcium salt deposition in coronary atherosclerotic plaques.It is a highly specific marker of coronary atherosclerosis.The degree of coronary artery calcification can be quantified and presented as coronary artery calcification score(CACS),which is closely related to cognitive impairment(CI).The pathogenesis and influencing factors between CAC and CI have not been elucidated.This paper reviews the research progress of CAC with CI from the perspective of brain magnetic resonance imaging,in order to further study the neuropathological mechanism of CAC with CI.