2017~2021年某医院白念珠菌的菌株分布及耐药监测

Distribution and Drug Resistance Monitoring of Candida Albicans in a Hospital From 2017 to 2021

目的分析某医院2017—2021年白念珠菌的菌株分布以及耐药性,为临床合理用药和控制白念珠菌感染提供依据。方法回顾性分析某医院2017年1月至2021年12月白念珠菌的菌株分布和药敏实验结果。结果共分离出2415株白念珠菌。标本主要来源于痰液、尿液和分泌物,分别占39.01%(942/2415)、31.14%(752/2415)、17.31%(418/2415)。临床科室分布主要来自保健病房、呼吸与危重症病房和妇产科,分别占30.72%(742/2415)、19.50%(471/2415)和14.00%(338/2415)。白色念珠菌对5-氟胞嘧啶、两性霉素B、伏立康唑、氟康唑和伊曲康唑5种抗真菌药物耐药率分别为0.01%~1.48%、0.01%~0.42%、0.87%~2.74%、0.21%~1.24%和1.01%~3.37%。白念珠菌的耐药变迁情况不明显。结论本院最常见的念珠菌为白念珠菌,2020年和2021年两年的分离比例较前三年呈下降趋势,白念珠菌对抗真菌药物的耐药率总体较低。

Objective To analyze the distribution and drug resistance of Candida albicans in a hospital from 2017 to 2021,and to provide evidence for rational drug use and control of Candida albicans infection.Methods The distribution of Candida albicans strains and the results of drug sensitivity test in a hospital from January 2017 to December 2021 were analyzed retrospectively.Results A total of 2415 strains of Candida albicans were isolated.The samples were mainly derived from sputum,urine and secretions,accounting for 39.01%(942/2415),31.14%(752/2415)and 17.31%(418/2415),respectively.The clinical departments were mainly from health ward,respiratory and critical ward and obstetrics and gynecology,accounting for 30.72%(742/2415),19.50%(471/2415)and 14.00%(338/2415),respectively.The resistance rates of Candida albicans to 5 antifungal agents were 0.01%to 1.48%,0.01%to 0.42%,0.87%to 2.74%,0.21%to 1.24%and 1.01%to 3.37%,respectively.The change of drug resistance of Candida albicans was not obvious.Conclusion The most common candida albicans in our hospital is Candida albicans,and the proportion of isolates in 2020 and 2021 shows a decreasing trend compared with the previous three years.The resistance rate of Candida albicans to antifungal drugs is generally low.