变异链球菌聚酮/非核糖体肽类次级代谢产物研究进展

Latest Findings on Polyketides/Non-ribosomal Peptides That Are Secondary Metabolites of Streptococcus mutans

龋病是在以细菌为主的多因素影响下,牙体硬组织发生的慢性感染性疾病。变异链球菌被认为是引起龋病的主要病原体。次级代谢产物是由变异链球菌合成的一类小分子化合物,包括细菌素和聚酮/非核糖体肽。目前已发现的变异链球菌聚酮/非核糖体肽类次级代谢产物主要有mutanobactin、mutanocyclin和mutanofactin,分别由mub、muc和muf基因簇合成,参与细菌菌种间竞争、氧化应激、生物膜形成等多项生理活动。本文就变异链球菌3种主要聚酮/非核糖体肽类次级代谢产物mutanobactin、mutanocyclin和mutanofactin的合成、功能和调控等方面进行综述,为进一步研究变异链球菌致龋机制和龋病防治提供新的思路。

Dental caries is a chronic infectious disease that occurs in the hard tissue of teeth under the influence of multiple factors,among which bacteria being a key factor.Streptococcus mutans(S.mutans)is considered a major pathogen that causes caries.Secondary metabolites,including bacteriocins and polyketides/non-ribosomal peptides,are a class of small-molecule compounds synthesized by S.mutans.To date,polyketides/non-ribosomal peptides identified in S.mutans include mutanobactin,mutanocyclin,and mutanofactin,which are synthesized by the mub,muc,and muf biosynthetic gene clusters,respectively.These polyketides/non-ribosomal peptides play important roles in bacterial interspecies competition,oxidative stress,and biofilm formation.In this review,we provided an overview of the synthesis,function and regulation of three polyketides/non-ribosomal peptides of S.mutans,including mutanobactin,mutanocyclin,and mutanofactin,aiming to provide new insights into the cariogenic mechanism of S.mutans and to promote the better management of dental caries.