基于幂律模型解析有氧运动抵抗阿尔茨海默病的动物实验

The power-law model-based analysis of aerobic exercise against Alzheimer’s disease in animal experiments

背景:阴阳和中庸是中华文化的核心概念,但目前缺少与现代科学对接的桥梁。幂律模型在复杂系统科学中具有良好的鲁棒性或抗干扰能力,提示与阴阳和中庸密切相关。目的:通过幂律模型分析长期有氧运动抵抗阿尔茨海默病模型的阴阳辨证特征,探讨幂律模型阴阳学说在人体复杂系统中的潜在作用。方法:借鉴阴阳学说成双成对的思路、关系理性和中庸之道,文中用幂律表征每一对参数,将引起幂律系数和指数变化的因素称为阴阳因,提出了人体阴阳的参数对模型,并应用于阿尔茨海默病动物实验研究。人体的参数构成参数空间,将参数空间的几何均值定义为参数空间的时中。结果与结论:①阴阳是客观参数幂律关系的主观感觉;②2个子空间时中的阴阳属性相对于2个子空间的联合空间的时中而存在;③2个子空间时中的阴平阳秘或阴阳失调分别对应于2个子空间时中的同级幂律或升级幂律;④动物实验数据结果分析,阿尔茨海默病造模可以造成阴阳失调,造模前的长期游泳运动可以抵抗阿尔茨海默病造模对阴阳两类参数的改变;⑤上述结果显示,人体复杂系统参数对幂律模型阴阳学说的合理解释可以用于数据空间的阴阳辨证,客观参数时中的幂律关系可以表征其主观感觉的阴阳特征。

BACKGROUND:Yin-Yang and the golden mean are the core concepts of Chinese culture,but there is a lack of a bridge connecting with modern science.The power-law model has good robustness or anti-interference ability in complex system science,suggesting that it is closely related to Yin-Yang and the golden mean.OBJECTIVE:To analyze the Yin-Yang dialectical characteristics of long-term aerobic exercise against Alzheimer’s disease based on the power-law model and to discuss the potential role of Yin-Yang theory of power-law model in the complex systems of the human body.METHODS:Referring to the theory of Yin-Yang,the relationship rationality and the golden mean,this paper uses power law to characterize each pair of parameters,and the factors that cause the power law coefficient and index changes are referred to as Yin-Yang causes.Then,a parametric pair model of human Yin-Yang is proposed and applied to experimental animal studies of Alzheimer’s disease.The parameters of the human body constitute the parameter space,and the geometric mean of the parameter space is defined as the golden center of the parameter space.RESULT AND CONCLUSION:Yin and Yang are subjective feelings of power-law relationship of objective parameters.Yin-Yang attribute of two subspaces exists in relation to the joint space of two subspaces.Yin-Yang secret or Yin-Yang imbalance in two subspaces correspond to the same-level power law or upgraded power law in two subspaces respectively.Animal experimental data shows that Alzheimer’s disease modeling can cause Yin-Yang imbalance,and habitual swimming before modeling can resist the changes in Yin-Yang parameters caused by Alzheimer’s disease modeling.The above results indicate that the reasonable explanation of Yin-Yang theory of power-law model by human complex system parameters can be used for Yin-Yang dialectic in data space and the power-law relationship in objective parameters can represent the Yin-Yang characteristics of subjective feelings.