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(叔丁氧羰基)-L-天冬酰胺的合成研究

Study on the Synthesis of(Tert-Butoxycarbonyl)-L-Asparagine
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摘要 研究了(叔丁氧羰基)-L-天冬酰胺的合成,并对该工艺条件进行了方法学研究。L-天冬酰胺、氢氧化钠和二碳酸二叔丁酯溶于水和1,4-二氧六环中,在20℃下反应12h。该工艺方法得到84%的收率,且反应条件简单温和,工艺设备成本廉价,实现了操作简单、经济实惠和绿色环保的目的。 The synthesis of(tert-Butoxycarbonyl)-L-asparagine was studied,and the process conditions were methodologically studied.L-asparagine,sodium hydroxide and di-tert-butyl dicarbonate were dissolved in water and 1,4-dioxane,and reacted at 20℃for 12 hours to obtain a yield of 84%.This process method has the advantages of simple and mild reaction conditions and low cost of process equipment.Therefore,the process method achieves the purpose of simple operation,economic and green environmental protection.
作者 王金榕 张凤华 李飞 于芳 Wang Jinrong;Zhang Fenghua;Li Fei;Yu Fang(Petrochemical College,Liaoning Petrochemical University,Liaoning,113001)
出处 《当代化工研究》 2023年第9期160-162,共3页 Modern Chemical Research
关键词 L-天冬酰胺 二碳酸二叔丁酯 N-Boc-天冬酰胺 L-Asparagine Di-tert-butyl dicarbonate N-Boc-asparagine
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