近十年半枝莲抗肿瘤作用机制研究概况

A survey of anti-tumor mechanism of Scutellaria barbata in recent ten years

半枝莲在调控肿瘤细胞的生长、侵袭转移、免疫功能和抗化疗药物耐药等方面发挥重要的作用,具有多成分、多效应、多途径、多靶点和毒副作用小的优势。半枝莲在临床中是一种极具开发潜力的药用资源,具有广阔的应用前景。本文现从抑制肿瘤细胞增殖,阻滞细胞生长周期,诱导细胞凋亡,促进细胞自噬,抑制血管生成,抑制细胞迁移和侵袭,调节免疫、抗化疗药物耐药等药理作用机制着手,对近十年的国内外关于半枝莲抗肿瘤作用机制方面的研究进行综述,发现半枝莲可通过调控Wnt/胞内β-连锁蛋白(β-catenin)、microRNA、磷脂酰肌醇-3激酶(phosphatidylinositol-3-kinases,PI3K)/蛋白激酶B(protein kinase B,Akt)和刺猬因子(sonic hedgehog,SHH)相关信号通路抑制肿瘤细胞生长。此外,半枝莲还能通过抑制肿瘤细胞运动相关蛋白和细胞因子,调节肿瘤细胞分解酶的活性及分解酶/分解酶抑制剂的平衡,发挥抑制细胞迁移和侵袭的作用,并能通过调节免疫相关细胞因子水平和抑制P-糖蛋白(P-glycoprotein,P-gp)的外排逆转化疗药物耐药。在今后的研究中有必要从转录组学、基因组学和蛋白组学等分子水平进一步探讨和验证其抗肿瘤作用机制,为临床应用和进一步新型靶向药物研究提供有力的证据支持。

Scutellaria barbata plays an important role in regulating the growth,invasion and metastasis of tumor cells,immune function and resistance to chemotherapeutic drugs.It has the advantages of multi-component,multi-effect,multi-channel,multi-target and small toxic and side effects.Scutellaria barbata is a kind of medicinal resource with great development potential in clinic and has broad application prospects.In this paper,we reviewed the research on anti-tumor mechanism of Scutellaria barbata in the past decade at home and abroad,starting from the pharmacological mechanism of inhibiting tumor cell proliferation,blocking cell growth cycle,inducing cell apoptosis,promoting cell autophagy,inhibiting angiogenesis,inhibiting cell migration and invasion,regulating immunity,and resisting chemotherapy drug resistance,and found that Scutellaria barbata can regulate Wnt/β-Catenin,miRNA,PI3K/AKT and SHH related signal pathways,tumor cell growth.In addition,Scutellaria barbata can also inhibit cell migration and invasion by inhibiting tumor cell motion-related proteins and cytokines,regulating the activity of tumor cell decomposing enzyme and the balance of decomposing enzyme/decomposing enzyme inhibitors,and reverse the resistance of chemotherapy drugs by regulating the level of immune-related cytokines and inhibiting the efflux of P-gp.In future research,it is necessary to explore and verify its anti-tumor mechanism at the molecular level of transcriptomics,genomics and proteomics,so as to provide strong evidence for clinical application and further research and development of new targeted drugs.