UGRP1与成人隐匿性自身免疫性糖尿病的相关性

The correlation research of UGRP1 with latent autoimmune diabetes in adults

目的探讨子宫球蛋白相关蛋白1(UGRP1)与成人隐匿性自身免疫性糖尿病(LADA)的相关性。方法选取124例受试者,其中LADA患者45例为LADA组,2型糖尿病(T2DM)患者41例为T2DM组,无糖尿病的健康人38例为对照组,分别比较3组间一般资料、糖尿病相关指标、血清UGRP1水平。采用Spearman相关性分析血清UGRP1与糖尿病相关指标的关系。采用二元Logistic回归分析UGRP1是否为LADA发病的独立危险因素。采用ROC曲线分析探讨UGRP1在LADA中的诊断价值。结果3组间体质量指数(BMI)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FBG)及餐后2 h血糖(2hPBG)、C肽(FCP)及餐后2 h C肽(2hCP)、糖基化血红蛋白(HbA1c)、糖尿病抗体(GADAb、IA-2、ZnT8)指标比较,差异有统计学意义(P<0.05)。LADA组血清UGRP1水平高于对照组及T2DM组,差异有统计学意义(P<0.05)。Spearman相关性分析结果显示,糖尿病患者血清UGRP1水平与FCP、2hCP、GADAb、阳性糖尿病抗体数目相关。二元Logistic回归分析显示血清UGRP1水平为LADA发病的独立危险因素。ROC曲线分析结果提示UGRP1可作为诊断LADA较好的辅助指标。结论UGRP1可能与LADA的发病相关。

Objective To investigate the correlation of uteroglobulin-related protein 1(UGRP1)with latent autoimmune diabetes in adults(LADA).Methods 124 participants were selected,including 45 LADA patients as LADA group,41 type 2 diabetes mellitus(T2DM)patients as T2DM group and 38 healthy people without diabetes as control group.General information,diabetes related indicators and serum UGRP1 levels were compared among the three groups.Spearman correlation was used to analyze the relationship between serum UGRP1 and diabetes related indicators.Binary logistic regression was used to analyze whether UGRP1 could be an independent risk factor for LADA.The diagnostic value of UGRP1 in LADA was discussed by ROC curve analysis.Results There were significant differences in BMI,systolicpressure,diastolicpressure,fasting blood glucose,2h postprandial blood glucose,fasting C-peptide,2h postprandial C-peptide,HbA1c,diabetes antibodies(GADAb,IA-2,ZnT8)among the three groups(P<0.05).The level of serum UGRP1 in LADA group was significantly higher than that in control group and T2DM group(P<0.05).Spearman correlation analysis showed that the serum UGRP1 level of diabetes patients was related to fasting C-peptide,2h postprandial C-peptide,GADAb,the number of positive diabetes antibodies.Binary Logistic regression analysis showed that serum UGRP1 level was an independent risk factor for LADA.ROC curve analysis results suggested that UGRP1 could be used as a better assistant indicator for the diagnosis of LADA.Conclusion UGRP1 may be involved in the pathogenesis of LADA.