铁死亡在高血压发病中的作用

The role of ferroptosis in the pathogenesis of hypertension

铁死亡是一种新发现的铁依赖性的细胞程序性死亡方式,主要特征为细胞内铁超载、谷胱甘肽耗竭及脂质过氧化。高血压是心脑血管疾病发生的重要危险因素之一,越来越多的研究证明高血压与铁死亡密切相关。本文将综述铁死亡与高血压之间的联系,以及铁死亡影响高血压的相关可能机制,以期为高血压的治疗提供新的思路。

Ferroptosis is a newly discovered iron-dependent mode of programmed cell death,characterized by intracellular iron overload,glutathione depletion and lipid peroxidation.Hypertension is one of the important risk factors for the occurrence of cardiovascular and cerebrovascular diseases,and more and more studies have shown that hypertension is closely related to ferroptosis.This article will review the association between ferroptosis and hypertension,as well as the possible mechanisms of ferroptosis affecting hypertension,in order to provide new ideas for the treatment of hypertension.