糖尿病前期患者miR-126基因多态性与糖尿病发生的关系分析

Analysis of the relationship between miR-126 gene polymorphism and thedevelopment of diabetes mellitus in prediabetic patients

目的 探讨糖尿病前期患者微小RNA-126(miR-126)基因多态性与糖尿病发生的关系。方法 选取2021年2月至2022年2月该院收治的80例糖尿病前期患者作为研究组,80例糖尿病患者作为参考组,选取同期80例体检健康者作为对照组。对比3组临床特征、miR-126表达水平,以及miR-126不同基因型基因多态性与糖尿病的相关性,分析糖尿病前期患者发生糖尿病的危险因素。结果 研究组体重指数(BMI)、空腹血糖、甘油三酯、总胆固醇、胰岛素抵抗指数高于对照组,低于参考组,差异均有统计学意义(P<0.05),参考组体力活动者占比低于对照组,差异有统计学意义(P<0.05);研究组miR-126表达水平低于参考组,高于对照组,差异均有统计学意义(P<0.05);研究组、对照组GG基因型占比低于参考组,AG基因型占比高于参考组,差异均有统计学意义(P<0.05);糖尿病前期患者miR-126 GG、AG基因型与糖尿病发生呈正相关(P<0.05),miR-126 AA基因型与糖尿病发生无相关性(P>0.05);BMI、甘油三酯、总胆固醇、miR-126是糖尿病前期患者发生糖尿病的危险因素(P<0.05)。结论 糖尿病前期患者miR-126呈低表达,BMI、甘油三酯、总胆固醇、miR-126是糖尿病前期患者发生糖尿病的危险因素,miR-126 rs4636297基因多态性与糖尿病前期患者糖尿病发生具有相关性。

Objective To explore the relationship between microRNA-126(miR-126)gene polymorphism and the development of diabetes mellitus in prediabetic patients.Methods Eighty patients with prediabetes admitted to our hospital from February 2021 to February 2022 were selected as the study group,80 patients with diabetes mellitus as the reference group,and 80 healthy physical examiners were selected as the control group.Clinical features,miR-126 expression levels,and the correlation between gene polymorphisms of different miR-126 genotypes and diabetes in the three groups were compared,and the risk factors of diabetes in pre-diabetic patients were analyzed.Results Body mass index(BMI),fasting blood glucose,triglyceride,total cholesterol and insulin resistance index in the study group were higher than those in the control group,but lower than those in the reference group,with statistical significance(P<0.05).The proportion of physical activity in the reference group was significantly lower than that in the control group(P<0.05).The expression level of miR-126 in the study group were lower than those in the reference group,but higher than that in the control group,with statistical significance(P<0.05).The proportions of GG genotype in study group and control group were lower than those in reference group,and the proportion of AG genotype was higher than that in reference group,the differences were statistically significant(P<0.05).The GG and AG genotypes of miR-126 were positively correlated with the development of diabetic in prediabetic patients(P<0.05),while the AA genotype of miR-126 was not correlated with the development of diabetes(P>0.05).BMI,triglyceride,total cholesterol and miR-126 were risk factors for the development of diabetes in prediabetic patients(P<0.05).Conclusion MiR-126 is low expression in prediabetic patients,BMI,triglyceride,total cholesterol and miR-126 were risk factors for the development of diabetes in prediabetic patients.The miR-126 rs4636297 gene polymorphism is correlated with the development of diabetes in prediabetic patients.