摘要
GVNE反应液经脱水后,经超强质子酸催化,可不经结晶出GVNE直接与苯酚反应水解掉4位保护基,从而实现连续制备,从而减少了制备过程中溶剂损耗及能量消耗,所制备出产品与原工艺的差别。介绍了连续法中2种竞速反应的反应机理。
After dehydration of GVNE reaction solution,catalyzed by super proton acid,GVNE reacts directly with phenol without crystallization to hydrolyze off the 4-position protective group,thus realizing continuous preparation,thus reducing the solvent loss and energy consumption in the preparation process,and the product prepared is different from the original technology.The reaction mechanism of two kinds of racing reaction was introduced in detail in the continuous reaction method.
作者
白立瑶
张慧荣
Bai Liyao;Zhang Huirong(NCPC Hebei Huamin Pharmaceutical Corporation Ltd.,Shijiazhuang 052160,China)
出处
《煤炭与化工》
CAS
2023年第4期131-134,共4页
Coal and Chemical Industry