阻塞性睡眠呼吸暂停的脑血流灌注成像研究进展

Advances in cerebral perfusion imaging in obstructive sleep apnea

阻塞性睡眠呼吸暂停(OSA)是一种常见的睡眠呼吸障碍,可致局部脑血流量改变,脑血流灌注成像对于评估OSA严重程度及预后进展具有重要意义。目前应用于评估OSA患者脑血流灌注的成像技术主要包括单光子发射计算机断层显像、磁共振脑血流灌注成像等。本研究旨在对脑血流灌注成像技术在OSA的研究进展进行综述,客观分析各脑血流灌注技术的优势和局限,以期提高各技术在OSA的早期筛查、评价疾病严重程度以及预后进展的临床适用性,并展望未来研究方向和提出目前潜在的挑战。

Obstructive sleep apnea(OSA),a common sleep-disordered breathing,will cause changes in regional cerebral blood flow(CBF).Cerebral perfusion imaging is of great significance for assessing the severity and prognosis of OSA.The imaging techniques used to assess cerebral blood flow perfusion in OSA patients mainly include single photon emission computed tomography(SPECT)and magnetic resonance perfusion imaging.The application of cerebral perfusion imaging in OSA is overviewed based on the objective analysis on the advantages and limitations of various cerebral perfusion techniques,aiming to improve the clinical applicability of various imaging techniques in early screening,disease severity assessment,and evaluations of progression and prognosis.An outlook on the development trends and potential challenges are also put forward.