m6A修饰阅读蛋白YTH在结直肠癌中的机制研究进展

Research progress in the mechanism of m6A-modified reading protein YTH in colorectal cancer

N6-甲基腺苷(N6-methyladenosine,m6A)是真核生物mRNA和长链非编码RNA(lncRNAs)中最丰富的内部化学修饰,其过程由甲基转移酶、去甲基化酶和阅读蛋白参与完成,并依赖三者进行动态调控。其中YT521-B同源域(YT521-B homology,YTH)蛋白是一类成熟的m6A阅读蛋白,它可以特异性地识别含有m6A的RNA并介导其行使功能,与多种肿瘤发生发展有关。然而,关于YTH蛋白在结直肠癌中的作用知之甚少。本文综述了YTH蛋白在结直肠癌中的相关通路机制,为结直肠癌个性化治疗提供借鉴。

N6-methyladenosine(m6A)is the most abundant internal chemical modifications in eukaryotic mRNA and long non-coding RNAs(lncRNAs),and its process is controlled by methyltransferase,demethylase and reader proteins are involved in the completion and rely on the three dynamic regulation.Among them,the YT521-B homology domain(YTH)protein is a kind of mature m6A reading protein,which can specifically recognize m6A-containing RNA and mediate its function,and is related to the occurrence and development of various tumors.However,little is known about the role of YTH proteins in colorectal cancer.This article reviews the structure,function and related pathway mechanism of the YTH protein in colorectal cancer,so as to provide the reference for the personalized treatment for colorectal cancer.