铜依赖性细胞死亡及铜在乳腺癌治疗中的研究现状

Research status of copper-dependent cell death and copper in breast cancer

目的铜是一种参与多种生物过程的金属元素,维持铜离子平衡是保持机体健康的重要条件,铜与多种疾病的发生发展相关,其中包括恶性肿瘤。“铜死亡”是最新提出的一种依赖于细胞内铜积累的新型细胞死亡方式。研究表明,铜的动态平衡与乳腺癌的发生发展有关,铜在乳腺癌治疗中的研究也日益兴起,本文主要就铜依赖性细胞死亡的发生机制及铜在乳腺癌治疗中的研究现状作一综述。

Copper is a metal element involved in a variety of biological processes.Maintaining the balance of copper ions is an important condition for maintaining the health of body.Copper is related to the occurrence and development of many diseases,including malignant tumors."Cuprotosis"is a newly proposed cell death mode that depends on the accumulation of intracellular copper.Studies have shown that the dynamic balance of copper is related to the occurrence and development of breast cancer,and the research on copper in the treatment of breast cancer is also rising.This article mainly summarizes the mechanism of copper-dependent cell death and the research status of copper in breast cancer.