探讨血常规联合相关生化指标对新冠病毒感染者的筛查及诊断价值

To explore the value of blood routine combined with related biochemical indicators in screening and diagnosis of patients with new coronavirus infection

目的:探讨血常规联合相关生化指标对新冠病毒感染者的筛查及诊断价值。方法:选取符合标准的洛阳市30例轻症新冠病毒感染者及洛阳东方医院疑似患者2次核酸检测均阴性出院的患者30例;共60例患者。其中男34例,女26例,年龄20~86岁,平均(43.2±12.7)岁,分为确诊组和对照组。收集及研究60例患者的白细胞、淋巴细胞计数、血管紧张素II、前白蛋白、乳酸脱氢酶、C-反应蛋白、红细胞沉降率等。采用受试者工作特征曲线(ROC)衡量淋巴细胞计数及联合生化指标对于新冠病毒感染的筛查及诊断,运用Z检验对四种评分系统曲线下面积(AUC)差异进行比较。结果:白细胞、淋巴细胞、血管紧张素II、前白蛋白、乳酸脱氢酶、C-反应蛋白、红细胞沉降率对应的AUC曲线下面积分别为:0.866、0.811、0.837、0.709、0.837、0.911、0.857;从中我们可以得出单项评估对新冠肺炎的诊断有一定的临床意义。LY联合ACE2、LY联合PA、LY联合LDH、LY联合CRP、LY联合ESR的曲线下面积分别是0.966、0.983、0.998、0.922、0.996,从中我们可以得出联合优于单项,联合后对新冠肺炎的评估有较好的临床价值。结论:血常规联合相关生化指标对于对新冠病毒感染者的诊断具有重要临床意义,以指导对新冠肺炎的早期诊断。

Objective:To explore the value of blood routine combined with related biochemical indicators in screening and diagnosis of patients with new coronavirus infection.Methods:30 cases of patients with mild new coronavirus infection in Luoyang City and suspected patients from Luoyang Dongfang Hospital who were discharged from the hospital with negative nucleic acid tests in 2 times were selected,and a total of 60 patients were selected.There were 34 males and 26 females,aged 20-86 years,with an average of(43.2±12.7)years.They were divided into diagnosis group and control group.Collect and study the white blood cell,lymphocyte count,angiotensin II,prealbumin,lactate dehydrogenase,C-reactive protein,erythrocyte sedimentation rate,etc.of 60 patients.Receiver operating characteristic curve(ROC)was used to measure lymphocyte count and combined biochemical indicators for screening and diagnosis of COVID-19 infection.Z test was used to compare the difference of the area under the four scoring systems(AUC).Results:The area under the AUC curve corresponding to white blood cells,lymphocytes,angiotensin II,prealbumin,lactate dehydrogenase,C-reactive protein,and erythrocyte sedimentation rate are 0.866,0.811,0.837,0.709,0.837,0.911,0.857,respectively;From this,we can conclude that a single assessment has certain clinical significance for the diagnosis of new coronary pneumonia.The area under the curve of LY combined with ACE2,LY combined with PA,LY combined with LDH,LY combined with CRP,and LY combined with ESR are 0.966,0.983,0.998,0.922,and 0.996,respectively.From this we can conclude that the combination is better than the single item,and the combination is better for new coronary pneumonia The evaluation has good clinical value.Conclusion:The combination of blood routine and related biochemical indicators has important clinical significance for the diagnosis of patients with new coronavirus infection,and guides the early diagnosis of new coronary pneumonia.