拜阿司匹林肠溶片、氯吡格雷单独及联合治疗急性缺血性脑卒中的效果及对血小板聚集的影响

Efficacy of Bay Aspirin Enteric-coated Tablets and Clopidogrel Alone and in Combination in the Treatment of Acute Ischemic Stroke and its Effect on Platelet Aggregation

目的 探讨对急性缺血性脑卒中采用拜阿司匹林肠溶片、氯吡格雷单独及联合治疗的临床效果及对血小板聚集影响。方法选取2022年1~12月我院收治的180例急性缺血性脑卒中患者作为本研究对象,按随机数表法将其分为3组,分别为A组、B组及C组,各60例。A组使用拜阿司匹林肠溶片联合氯吡格雷治疗,B使用拜阿司匹林肠溶片治疗,C组使用氯吡格雷治疗。对比3组神经功能、临床疗效、血小板聚集功能、血脂水平及不良反应发生率。结果 A组NIHSS评分、Barthel指数与B组、C组比较差异有统计学意义(P <0.05),且B组与C组比较差异无统计学意义(P> 0.05);A组MARAA显著低于B组、C组、MARADP显著高于B组、C组(P <0.05),且B组、C组对比差异无统计学意义(P> 0.05);A组临床总有效率为96.67%显著高于B组临床总有效率75.00%、C组临床总有效率78.33%(P <0.05),且B组、C组对比差异无统计学意义(P> 0.05);A组TG、TC、LDL-C与B组、C组比较差异有统计学意义(P <0.05),且B组与C组比较差异无统计学意义(P> 0.05);A组不良反应发生率为1.67%显著低于B组不良反应发生率28.33%、C组不良反应发生率30.00%(P <0.05),且B组、C组对比差异无统计学意义(P> 0.05)。结论 拜阿司匹林联合氯吡格雷治疗急性缺血性脑卒中较单独治疗的临床效果更为显著。

Objective To investigate the clinical efficacy and effect on platelet aggregation of acute ischemic stroke treated with bye aspirin entericcoated tablets and clopidogrel alone and in combination.Methods A total of 180 patients with acute ischemic stroke admitted to our hospital from January 2022 to December 2022 were selected as the subjects of this study and divided into 3 groups according to the random number table method:group A,group B and group C,60 cases in each group.Group A was treated with baiaspirin enteric tablets combined with clopidogrel,group B was treated with baiaspirin enteric tablets and group C was treated with clopidogrel.The neurological function,clinical efficacy,platelet aggregation function,lipid level and incidence of adverse effects were compared among the 3 groups.Results The difference between NIHSS score and Barthel index in group A and group B and group C was statistically significant(P<0.05),and the difference between group B and group C was not statistically significant(P>0.05),and the MARAA in group A was significantly lower than that in group B,group C and MARAP(P<0.05),and the difference between group B and group C was not statistically significant(P>0.05),and the total clinical effective rate of group A was 96.67%It was significantly higher than the total clinical effective rate of 75.00%in group B and 78.33%in group C(P<0.05),and there was no significant difference between group B and group C(P>0.05),the difference between group A TG,TC,LDL-C and Group B and Group C was statistically significant(P<0.05),and the difference between group B and group C was not statistically significant(P>0.05);the incidence of adverse reactions in group A was 1.67%,which was significantly lower than that of group B with 28.33%,The incidence of adverse reactions in group C was 30.00%(P<0.05),and there was no significant difference between group B and group C(P>0.05).Conclusion The clinical efficacy of bye aspirin combined with clopidogrel in the treatment of acute ischemic stroke is more significant than that of treatment alone.