小剂量黄体酮治疗无排卵型月经不调的临床效果

Clinical Effect of Low Dose Progesterone on Anovulatory Menstrual Disorder

目的 分析小剂量黄体酮应用于治疗无排卵型月经不调的临床效果及对患者相关指标和预后的影响。方法 纳入2020年6月至2022年6月就诊我院妇科门诊的无排卵型月经不调患者100例为研究对象,行对比性治疗研究,依据患者的就诊顺序动态随机化分组法将其均分设置对照组、观察组,各50例。对照组给予常规剂量黄体酮治疗(200 mg/d),观察组给予小剂量黄体酮治疗(100 mg/d)。比较两组无排卵型月经不调患者康复有效率、激素指标、月经情况、子宫内膜厚度、不良反应和预后生活质量差异。结果 治疗后,两组无排卵型月经不调患者的康复有效率、雌二醇、卵泡刺激素、促黄体生成素指标和月经周期、月经量、月经持续时间等指标及子宫内膜厚度比较差异无统计学意义,P> 0.05。观察组无排卵型月经不调患者头晕乏力、恶心呕吐、腹痛等不良反应发生率低于对照组,P <0.05。观察组无排卵型月经不调患者的预后GQOLI-74生活质量评分高于对照组,P <0.05。结论小剂量黄体酮应用于治疗无排卵型月经不调的临床效果与大剂量治疗并无差异,均能优化患者的激素指标、改善月经情况和子宫内膜厚度,但小剂量治疗的安全性高,患者的预后生活质量更高。

Objective To analyze the clinical effect of low dose progesterone in the treatment of anovulatory menstrual disorder and its impact on related indicators and prognosis of patients.Methods A total of 100 patients with anovulatory dysmenorrhea who visited gynecological clinics during the study period from June 2020 to June 2022 were included in a comparative treatment study.They were divided into a control group and an observation group based on the dynamic randomization grouping method of the patient's visit order,with 50 patients in each group.The control group was treated with routine dose of progesterone(200 mg/d),while the observation group was treated with low dose of progesterone(100 mg/d).Compare the differences between the two groups in terms of rehabilitation effectiveness,hormone indicators,menstrual status,endometrial thickness,adverse reactions,and prognosis quality of life scores in patients with anovulatory menstrual disorder.Results After treatment,there was no difference in the recovery efficiency,estradiol,follicle-stimulating hormone,luteinizing hormone indexes and menstrual cycle,menstrual volume,menstrual duration and endometrial thickness between the two groups of patients with anovulatory menstrual disorders(P>0.05).The incidence of adverse reactions such as dizziness,fatigue,nausea,vomiting,and abdominal pain in patients with anovulatory menstrual disorder in the observation group was significantly lower than that in the control group(P<0.05).The GQOLI-74 quality of life score of patients with anovulatory menstrual disorder in the observation group was significantly higher than that in the control group(P<0.05).Conclusion The clinical efficacy of low dose progesterone in the treatment of anovulatory dysmenorrhea is not significantly different from that of high dose progesterone,both of which can optimize the hormonal parameters,improve menstrual status,and endometrial thickness of patients.However,low dose progesterone has a high safety and a higher prognosis quality of life for patients.