马来酸麦角新碱联合缩宫素在剖宫产手术产妇产后出血预防中的应用效果

Effect of Ergometrine Maleate Combined with Oxytocin on Prevention of Postpartum Hemorrhage in Parturients undergoing Cesarean Section

目的 探讨剖宫产手术产妇采取马来酸麦角新碱联合缩宫素对于预防产后出血的临床效果。方法 选取2019年4月至2022年10月在我院进行剖宫产手术的产妇268例作为研究对象,根据预防产妇产后出血药物治疗方式的不同将268例剖宫产手术产妇分为两组,即联合治疗组(采取马来酸麦角新碱联合缩宫素治疗)和对照组(采取缩宫素治疗),每组134例。治疗后,比较两组产妇的产后出血预防效果,即产妇产后2 h内的出血量、产后24 h内的出血量;同时,对比两组产妇在治疗前后的心率以及血氧饱和度的变化情况、产妇出现产后出血的发生率以及在使用药物后产妇出现的不良反应变化。结果 联合治疗组产妇产后2 h与产后24 h的出血量预防效果明显优于对照组(P <0.05);联合治疗组与对照组产妇在治疗前后的心率以及血氧饱和度变化差异较小,两组产妇治疗前后的心率以及血氧饱和度对比差异无统计学意义(P> 0.05);联合治疗组产妇的产后出血发生率明显低于对照组(P <0.05);同时联合治疗组的不良反应发生率为6.72%,低于对照组产妇的不良反应发生率9.70%,但是两组不良反应发生率对比差异无统计学意义(P> 0.05)。结论 针对剖宫产手术产妇而言,马来酸麦角新碱联合缩宫素对产后出血的预防效果显著,不仅能够有效的降低产妇在产后的出血发生率,还能提高产妇的临床预后效果。

Objective To explore the clinical effect of ergometrine maleate combined with oxytocin in preventing postpartum hemorrhage in cesarean section.Methods A total of 268 puerperas undergoing cesarean section in our hospital from April 2019 to October 2022 were selected as the study subjects.According to the different drug treatment methods for preventing postpartum hemorrhage,268 puerperas undergoing cesarean section were divided into two groups,namely,the combined treatment group(treated with ergotine maleate and oxytocin)and the reference group(treated with oxytocin),with 134 cases in each group.After treatment,compare the prevention effect of postpartum hemorrhage between the two groups,namely,the amount of postpartum hemorrhage within 2 hours and the amount of postpartum hemorrhage within 24 hours.At the same time,the changes of heart rate and blood oxygen saturation before and after treatment,the incidence of postpartum hemorrhage and the changes of adverse reactions after drug use were compared between the two groups.Results The prevention effect of hemorrhage volume in the combined treatment group was significantly better than that in the control group at 2 hours and 24 hours postpartum(P<0.05).The difference of heart rate and blood oxygen saturation between the combined treatment group and the reference group before and after treatment is small,and the difference of heart rate and blood oxygen saturation between the two groups before and after treatment is not significant(P>0.05).The incidence of postpartum hemorrhage in the combined treatment group was significantly lower than that in the reference group,the incidence of postpartum hemorrhage in the two groups was significantly different(P<0.05).At the same time,the incidence of adverse reactions in the combined treatment group was 6.72%,which was lower than 9.70%in the reference group,but there was no significant difference in the incidence of adverse reactions between the two groups,so there was no statistical significance(P>0.05).Conclusion For the parturients undergoing cesarean section,ergometrine maleate combined with oxytocin has a relatively significant effect on the prevention of postpartum hemorrhage.It can not only effectively reduce the incidence of postpartum hemorrhage in parturients,but also improve the clinical prognosis of parturients,which is worthy of clinical promotion and application.