地仲强骨胶囊联合常规西药治疗绝经后骨质疏松症患者的效果

Effects of Dizhong Qianggu capsules combined with conventional Western medicine in treatment of postmenopausal osteoporosis

目的:观察地仲强骨胶囊联合常规西药治疗绝经后骨质疏松症患者的效果。方法:选取2019年10月至2020年11月该院收治的126例绝经后骨质疏松症患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各63例。对照组采用常规西药(骨化三醇软胶囊+阿仑膦酸钠片)治疗,观察组在对照组基础上采用地仲强骨胶囊治疗。比较两组临床疗效、治疗前后骨密度(腰椎L2~4和股骨颈)、骨代谢指标[碱性磷酸酶(ALP)、骨钙素(BGP)、β胶原降解产物(β-CTX)、Ⅰ型胶原交联N-末端肽(NTX)]水平、生命质量[简明健康调查表(SF-36)]评分,以及不良反应发生率。结果:观察组治疗总有效率为88.89%(56/63),高于对照组的74.60%(47/63),差异有统计学意义(P<0.05);治疗后,两组腰椎L2~4和股骨颈骨密度均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组血清ALP、β-CTX、NTX水平均低于治疗前,且观察组低于对照组,两组血清BGP水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组生理机能、生理职能、精力及躯体疼痛等SF-36各维度评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:地仲强骨胶囊联合常规西药治疗绝经后骨质疏松症患者可提高治疗总有效率、骨密度和生命质量评分,改善骨代谢指标水平,效果优于单纯常规西药治疗。

Objective:To observe effects of Dizhong Qianggu capsules combined with conventional Western medicine in treatment of postmenopausal osteoporosis.Methods:A prospective study was conducted on 126 patients with postmenopausal osteoporosis admitted to the hospital from October 2019 to November 2020.They were divided into control group and observation group according to the random number table method,63 cases in each.The control group was treated with conventional Western medicine(Calcitriol soft capsules+Alendronate sodium tablets),while the observation group was treated with Dizhong Qianggu capsules on the basis of that of the control group.The clinical efficacy,the bone mineral density(lumbar L2-4 and femoral neck)before and after the treatment,the bone metabolism index levels[alkaline phosphatase(ALP),osteocalcin(BGP),β-collagen degradation products(β-CTX),type I collagen cross-linked N-terminal peptide(NTX)],the quality of life[short form health survey(SF-36)]score,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 88.89%(56/63),which was higher than 74.60%(47/63)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the bone mineral density of lumbar spine L2-4 and femoral neck in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of serum ALP,β-CTX and NTX in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the serum BGP levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the SF-36 scores of physiological function,physiological role,vitality and body pain in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Dizhong Qianggu capsule combined with conventional Western medicine in the treatment of postmenopausal osteoporosis can improve the total effective rate,the bone mineral density and the quality of life score,and improve the levels of bone metabolism indexes.Moreover,it is superior to single conventional Western medicine treatment.