99Tc m-硫胶体显像联合超声造影检查在乳腺癌前哨淋巴结诊断中的效能

Efficacy of 99Tcm-sulfur colloid imaging combined with contrast-enhanced ultrasound in diagnosis of sentinel lymph nodes of breast cancer

目的:分析99Tcm-硫胶体显像联合超声造影检查在乳腺癌前哨淋巴结诊断中的效能。方法:选取2019年1月至2020年7月该院收治的80例疑似早期乳腺癌患者进行前瞻性研究,所有患者均行99Tcm-硫胶体显像和超声造影检查,以病理学检查结果作为金标准,分析99Tcm-硫胶体显像联合超声造影检查在乳腺癌前哨淋巴结诊断中的效能。结果:病理学检查结果显示,80例疑似早期乳腺癌患者中,69例确诊早期乳腺癌,占86.25%;超声造影检查结果显示,阳性44例,占55.00%;99Tcm-硫胶体显像检查结果显示,阳性54例,占78.26%;99Tcm-硫胶体显像联合超声造影检查结果显示,阳性57例,占82.61%;联合检查诊断乳腺癌前哨淋巴结的灵敏度、准确度、阳性预测值均高于超声造影与99Tcm-硫胶体显像单项检查诊断,且99Tcm-硫胶体显像检查高于超声造影检查,差异均有统计学意义(P<0.05);联合检查与99Tcm-硫胶体显像检查诊断乳腺癌前哨淋巴结的特异度、阴性预测值与超声造影检查比较,差异均无统计学意义(P>0.05);且联合检查诊断乳腺癌前哨淋巴结的特异度、阴性预测值与99Tcm-硫胶体显像检查比较,差异均无统计学意义(P>0.05)。结论:超声造影联合99Tcm-硫胶体显像检查诊断乳腺癌前哨淋巴结的效能高于两者单项检查诊断效能。

Objective:To analyze efficacy of 99Tcm-sulfur colloid imaging combined with contrast-enhanced ultrasound in diagnosis of sentinel lymph nodes of breast cancer.Methods:A prospective study was conducted on 80 patients with suspected early breast cancer admitted to the hospital from January 2019 to July 2020.All patients underwent 99Tcm-sulfur colloid imaging and contrast-enhanced ultrasound.Using the pathological examination results as gold standard,the efficacy of 99Tcm-sulfur colloid imaging combined with contrast-enhanced ultrasound in the diagnosis of sentinel lymph nodes of breast cancer was analyzed.Results:The gold standard showed that 69 of the 80 suspected early breast cancer patients were diagnosed with early breast cancer,accounting for 86.25%.The contrast-enhanced ultrasound showed that 44 cases were positive,accounting for 55.00%.The 99Tcm-sulfur colloid imaging showed that 54 cases were positive,accounting for 78.26%.The 99Tcm-sulfur colloid imaging combined with contrast-enhanced ultrasound showed that 57 cases were positive,accounting for 82.61%.The sensitivity,the accuracy and the positive predictive value of combined examination in the diagnosis of sentinel lymph nodes of breast cancer were higher than that of contrast-enhanced ultrasound and 99Tcm-sulfur colloid imaging,those of 99Tcm-sulfur colloid imaging were higher than those of contrastenhanced ultrasound,and the differences were statistically significant(P<0.05).There were no significant differences in the specificity and the negative predictive value between 99Tcm-ulfur colloid imaging and contrast-enhanced ultrasonography in the diagnosis of sentinel lymph nodes of breast cancer(P>0.05).There were no significant differences in the specificity and the negative predictive value in the diagnosis of sentinel lymph nodes of breast cancer between the combined detection and 99Tcm-sulfur colloid imaging(P>0.05).Conclusions:The efficacy of contrast-enhanced ultrasound combined with 99Tcm-sulfur colloid imaging in the diagnosis of sentinel lymph nodes of breast cancer is higher than that of single examinations.