早发型子痫前期孕妇双胎绒毛膜性、血清KLF-8水平及新生儿结局

The chorionicity of twins,the level of serum Krüppel like factor 8,and the neonatal outcomes of pregnant women with early onset preeclampsia

目的:研究双胎绒毛膜性及血清双向转录因子-8(KLF-8)水平与早发型子痫前期和新生儿结局。方法:选取本院2020年1月-2022年1月收治的112例早发型子痫前期患者临床资料作为子痫前期组,同期112例产前检查健康孕妇作为对照组。对比两组双胎绒毛膜性发生率以及血清KLF-8水平,子痫前期组不同新生儿结局患者临床特征并分析危险因素。结果:子痫前期组双胎绒毛膜性发生率12.5%高于对照组1.8%,血清KLF-8(15.63±2.14 pg/ml)低于对照组(36.63±2.04 pg/ml);子痫前期患者中新生儿结局不良组孕周和血清KLF-8水平均低于结局正常组,胎盘早剥、存在子痫病史以及双胎绒毛膜性发生率均高于结局正常组(均P<0.05)。logistic回归分析,早发型子痫前期患者双胎绒毛膜性、血清KLF-8降低、孕周小、胎盘早剥、子痫病史均是引起新生儿结局不良的独立危险因素(P<0.05)。结论:双胎绒毛膜性及血清KLF-8水平可能与早发型子痫前期和不良新生儿结局有一定关系。

Objective:To investigate the chorionicity of twins,the level of serum Krippel like factor 8(KLF 8),and the neonatal outcomes of pregnant women with early onset preeclampsia.Methods:The clinical data of 112 women with early onset preeclampsia from January 2020 to January 2022 were enrolled in experimental group,and other healthy pregnant women were included in control group during the same period.The rate of twin chorionicity and the serum KLF 8 level of the women were compared between two groups.The clinical characteristics of the women with different neonatal outcomes and the the risk factor associated with the early onset preeclampsia of the women were ana-lyzed.Results:The incidence of the twins’chorionicity(12.5%)of the women in the experimental group was signifi-cantly higher than than that(1.8%)of the women in the control group.The level of serum KLF 8(15.63±2.14 pg/ml)of the women in the experimental group was significantly lower than that(36.63±2.04 pg/ml)of the women in the control group.The gestational weeks and the serum KLF 8 level of the women with poor neonatal outcomes in the ex-perimental group were significantly lower than those of the women with normal neonatal outcomes(all P<0.05).Lo-gistic regression analysis showed that the twins'chorionicity,the decrease of serum KLF 8 level,the less gestational weeks,the placental abruption,and the eclampsia history of the women were all the independent risk factors of their poor neonatal outcomes(P<0.05).Conclusion:The twins’chorionicity and the serum KLF 8 level of the pregnant women may be related to their early onset preeclampsia and neonatal outcomes.