基于X射线相衬显微CT的肝肿瘤定量分析研究

Quantitative Analysis of Liver Tumors Based on X-ray Phase Contrast Micro-CT

新生血管对肿瘤提供无限生长的应用,但目前传统成像技术只能实现200μm的血管。本研究收集乏血型和富血型肝肿瘤标本20例,进行X射线相衬断层图像中可清晰显示肝肿瘤组织微血管的分布特征,与对应病理切片表现基本相吻合;通过灰度直方图和灰度-梯度共生矩阵提取图像特征,肿瘤图像特征统计结果表明两组存在显著差异(P<0.05),富血型肿瘤相比于乏血型肿瘤组织图像灰度分布不均匀、变化不规则、图像复杂度升高、清晰度降低,为进一步对不同类型肝肿瘤的诊断和特征评价提供数据支持和科学依据。

Neovascularization provides unlimited growth for tumors,but currently only 200μm vessels can be achieved by conventional imaging techniques.In this study,20 cases of liver tumor specimen with poor blood type and rich blood type are collected.X-ray phase-contrast tomography images could clearly show the distribution characteristics of microvessels in liver tumor tissue,which are basically consistent with the corresponding pathological section manifestations.The image features are extracted by grayscale histogram and grayscale-gradient co-occurrence matrix,and the statistical results of tumor image features show that there are significant differences between the two groups(P<0.05).Compared with poor-blood tumor tissue image,the rich-blood tumor tissue image has uneven gray distribution,irregular changes,increased image complexity,and decreased clarity,which provide data support and scientific basis for further diagnosis and characteristic evaluation of different types of liver tumors.